Abstract：
During the gestation and lactation period, the energy demand in pregnant and lactating bitches is elevated. Non-esterified fatty acids (NEFAs) are utilized either directly from the fed diet or from body fat storage. High NEFA concentration in the blood plasma leads to an increased risk for diseases. Therefore, measuring blood NEFA concentrations may be an indicator for a period of scarcity. The aim of this study is to explore if serum NEFA concentrations in healthy bitches change during gestation and lactation. Healthy pregnant and lactating bitches were sampled on three appointed dates around parturition. NEFA values were examined with a multiparameter clinical chemistry analyser. All statistical analyses were performed using R. Overall, 38 bitches were enrolled in the study. Twenty-one bitches were sampled on all three appointed dates. The median NEFA concentration antepartum was 0.73 mmol/L (IQR: 0.59, 1.01); during peak lactation, it was 0.57 mmol/L (IQR: 0.44, 0.82); and around weaning, it was 0.58 mmol/L (IQR: 0.46, 0.73). NEFA concentrations rose slightly with litter size in late gestation. Body condition score had no influence on observed NEFA values. We conclude that NEFA concentrations widely remain within reference ranges in well-fed pregnant and lactating bitches. Nevertheless, they may be a valuable parameter to assess the actual metabolic status of malnourished pregnant and lactating bitches.
摘要：
在妊娠期和哺乳期，孕妇和哺乳期母犬的能源需求增加。非酯化脂肪酸(NEFA)直接从饲喂饮食或从体内脂肪储存中利用。血浆中的高NEFA浓度导致疾病风险增加。因此,测量血液中NEFA浓度可能是稀缺时期的指标。这项研究的目的是探讨健康母犬在妊娠和哺乳期间的血清NEFA浓度是否发生变化。在分娩前后的三个指定日期对健康的孕妇和哺乳期母犬进行了采样。使用多参数临床化学分析仪检查NEFA值。所有统计分析均使用R进行。38只母犬被纳入研究。在所有三个指定日期对21只母狗进行了采样。产前NEFA浓度中位数为0.73mmol/L(IQR:0.59,1.01);在泌乳高峰期,它是0.57mmol/L(IQR：0.44，0.82)；在断奶前后，为0.58mmol/L(IQR:0.46,0.73)。妊娠后期，NEFA浓度随产仔数的增加而略有上升。身体状况评分对观察到的NEFA值没有影响。我们得出的结论是，在喂养良好的孕妇和哺乳期母犬中，NEFA浓度广泛保持在参考范围内。然而，它们可能是评估营养不良的孕妇和哺乳期母狗的实际代谢状况的有价值的参数。
