Abstract：
BACKGROUND: To investigate the potential utility of quantitative parameters obtained by 18F-fibroblast activation protein inhibitor positron emission tomography/computed tomography ([18F]AlF-NOTA-FAPI-04 PET/CT) in the assessment of organ involvement and disease activity in IgG4-related disease (IgG4-RD).
METHODS: This study enrolled patients who underwent [18F]AlF-NOTA-FAPI-04 PET/CT scans at the Department of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine from August 2021 to August 2022. The PET/CT images of the included patients were re-evaluated by PET center technicians, and the maximal standardized uptake value (SUVmax), metabolic lesion volume (MLV), and total lesion FAPI (TL-FAPI) were used to evaluate the involved organs and tissues that abnormally accumulated [18F]AlF-NOTA-FAPI-04. The clinical and laboratory data of patients are also systematically collected and analyzed.
RESULTS: Among the patients included in this study, 12 patients met the IgG4-RD classification criteria established by the American College of Rheumatology in 2019. Among them, 8 were males and 4 were females, with an average age of 59.3 ± 11.5 years. 50% of IgG4-RD patients were found with more organ involvement on PET/CT than physical examination, ultrasonography, and computed tomography. IgG4 levels (Rho = 0.594, p = 0.042) and IgG4-RI (Rho = 0.647, p = 0.023) were significantly positively correlated with TL-FAPI. After linear regression analysis, only TL-FAPI showed a predictive value of RI (R2 = 0.356, B = 0.008, p = 0.041).
CONCLUSIONS: [18F]AlF-NOTA-FAPI-04 PET/CT is a useful tool for identifying asymptomatic organ involvement and assessing disease activity. The TL-FAPI as an indicator was positively correlated with IgG4-RD disease activity.
METHODS: This study enrolled patients who underwent [18F]AlF-NOTA-FAPI-04 PET/CT scans at the Department of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine from August 2021 to August 2022. The PET/CT images of the included patients were re-evaluated by PET center technicians, and the maximal standardized uptake value (SUVmax), metabolic lesion volume (MLV), and total lesion FAPI (TL-FAPI) were used to evaluate the involved organs and tissues that abnormally accumulated [18F]AlF-NOTA-FAPI-04. The clinical and laboratory data of patients are also systematically collected and analyzed.
RESULTS: Among the patients included in this study, 12 patients met the IgG4-RD classification criteria established by the American College of Rheumatology in 2019. Among them, 8 were males and 4 were females, with an average age of 59.3 ± 11.5 years. 50% of IgG4-RD patients were found with more organ involvement on PET/CT than physical examination, ultrasonography, and computed tomography. IgG4 levels (Rho = 0.594, p = 0.042) and IgG4-RI (Rho = 0.647, p = 0.023) were significantly positively correlated with TL-FAPI. After linear regression analysis, only TL-FAPI showed a predictive value of RI (R2 = 0.356, B = 0.008, p = 0.041).
CONCLUSIONS: [18F]AlF-NOTA-FAPI-04 PET/CT is a useful tool for identifying asymptomatic organ involvement and assessing disease activity. The TL-FAPI as an indicator was positively correlated with IgG4-RD disease activity.
摘要：
背景：研究18F-成纤维细胞激活蛋白抑制剂正电子发射断层扫描/计算机断层扫描（[18F]AlF-NOTA-FAPI-04PET/CT）获得的定量参数在评估IgG4相关疾病（IgG4-RD）的器官受累和疾病活动中的潜在实用性。
方法：本研究招募了在风湿病科接受[18F]AlF-NOTA-FAPI-04PET/CT扫描的患者，第一附属医院,浙江大学医学院，2021年8月至2022年8月。纳入患者的PET/CT图像由PET中心技术人员重新评估，和最大标准化摄取值(SUVmax)，代谢病变体积（MLV），和总病变FAPI（TL-FAPI）用于评估异常积累的[18F]AlF-NOTA-FAPI-04的受累器官和组织。还系统地收集和分析了患者的临床和实验室数据。
结果：纳入本研究的患者中，12例患者符合2019年美国风湿病学会制定的IgG4-RD分类标准。其中,8个是男性，4个是女性，平均年龄为59.3±11.5岁。50％的IgG4-RD患者在PET/CT上发现器官受累多于体格检查，超声检查,和计算机断层扫描。IgG4水平(Rho=0.594,p=0.042)和IgG4-RI(Rho=0.647,p=0.023)与TL-FAPI呈显著正相关。经过线性回归分析，只有TL-FAPI显示RI的预测价值(R2=0.356,B=0.008,p=0.041)。
结论：[18F]AlF-NOTA-FAPI-04PET/CT是识别无症状器官受累和评估疾病活动的有用工具。以TL-FAPI为指标与IgG4-RD疾病活动度呈正相关。
方法：本研究招募了在风湿病科接受[18F]AlF-NOTA-FAPI-04PET/CT扫描的患者，第一附属医院,浙江大学医学院，2021年8月至2022年8月。纳入患者的PET/CT图像由PET中心技术人员重新评估，和最大标准化摄取值(SUVmax)，代谢病变体积（MLV），和总病变FAPI（TL-FAPI）用于评估异常积累的[18F]AlF-NOTA-FAPI-04的受累器官和组织。还系统地收集和分析了患者的临床和实验室数据。
结果：纳入本研究的患者中，12例患者符合2019年美国风湿病学会制定的IgG4-RD分类标准。其中,8个是男性，4个是女性，平均年龄为59.3±11.5岁。50％的IgG4-RD患者在PET/CT上发现器官受累多于体格检查，超声检查,和计算机断层扫描。IgG4水平(Rho=0.594,p=0.042)和IgG4-RI(Rho=0.647,p=0.023)与TL-FAPI呈显著正相关。经过线性回归分析，只有TL-FAPI显示RI的预测价值(R2=0.356,B=0.008,p=0.041)。
结论：[18F]AlF-NOTA-FAPI-04PET/CT是识别无症状器官受累和评估疾病活动的有用工具。以TL-FAPI为指标与IgG4-RD疾病活动度呈正相关。
