Abstract：
BACKGROUND: Interventions to increase physical activity are needed in adolescent and young adult survivors of childhood cancer who are largely inactive but at lifelong elevated risk of multiple chronic conditions improved by physical activity. The goals of the StepByStep study are to evaluate the effects of a 48-week distance-based, multi-component mobile health and social media behavioral intervention on physical activity, biomarkers of cardiometabolic health, and health-related quality of life.
METHODS: This ongoing study is a two-arm, prospective, multi-site randomized controlled trial. 384 childhood cancer survivors age ≥ 15 years and < 21 years who were 3-36 months off therapy and not meeting physical activity guidelines were enrolled. The trial will test the efficacy of a 24-week intensive multi-component physical activity intervention combining a wearable physical activity tracker, social media peer support group, and individualized goal setting followed by a 24-week maintenance phase of the intervention to improve outcomes. The control group receives the wearable physical activity tracker only.
CONCLUSIONS: There is a growing need for novel, developmentally appropriate interventions to increase physical activity and improve the health trajectory of adolescent and young adult survivors of childhood cancer. If efficacious, this portable and scalable intervention would be a much-needed tool to reduce the morbidity from cancer treatment and improve quality of life among survivors after treatment ends.
BACKGROUND: ClinicalTrials.gov Identifier: NCT04089358; COG Identifier: ALTE2031.
METHODS: This ongoing study is a two-arm, prospective, multi-site randomized controlled trial. 384 childhood cancer survivors age ≥ 15 years and < 21 years who were 3-36 months off therapy and not meeting physical activity guidelines were enrolled. The trial will test the efficacy of a 24-week intensive multi-component physical activity intervention combining a wearable physical activity tracker, social media peer support group, and individualized goal setting followed by a 24-week maintenance phase of the intervention to improve outcomes. The control group receives the wearable physical activity tracker only.
CONCLUSIONS: There is a growing need for novel, developmentally appropriate interventions to increase physical activity and improve the health trajectory of adolescent and young adult survivors of childhood cancer. If efficacious, this portable and scalable intervention would be a much-needed tool to reduce the morbidity from cancer treatment and improve quality of life among survivors after treatment ends.
BACKGROUND: ClinicalTrials.gov Identifier: NCT04089358; COG Identifier: ALTE2031.
摘要：
背景：儿童癌症的青少年和年轻成人幸存者需要增加体力活动的干预措施，他们大部分不活动，但因体力活动而改善多种慢性疾病的终身高风险。StepByStep研究的目标是评估基于48周距离的效果，多成分移动健康和社交媒体对身体活动的行为干预，心脏代谢健康的生物标志物，和健康相关的生活质量。
方法：这项正在进行的研究是一项双臂研究，prospective,多站点随机对照试验。384名年龄≥15岁和<21岁的儿童癌症幸存者参加了研究，他们在治疗后3-36个月不符合身体活动指南。该试验将测试结合可穿戴身体活动跟踪器的24周强化多组件身体活动干预的有效性，社交媒体同行支持小组，和个性化目标设定，然后进行为期24周的干预维持阶段，以改善结局。对照组仅接收可穿戴身体活动跟踪器。
结论：对小说的需求日益增长，发展适当的干预措施，以增加身体活动并改善儿童癌症的青少年和年轻成年幸存者的健康轨迹。如果有效，这种便携式和可扩展的干预措施将是降低癌症治疗发病率和改善治疗结束后幸存者生活质量的急需工具.
背景：ClinicalTrials.gov标识符：NCT04089358；COG标识符：ALTE2031。
方法：这项正在进行的研究是一项双臂研究，prospective,多站点随机对照试验。384名年龄≥15岁和<21岁的儿童癌症幸存者参加了研究，他们在治疗后3-36个月不符合身体活动指南。该试验将测试结合可穿戴身体活动跟踪器的24周强化多组件身体活动干预的有效性，社交媒体同行支持小组，和个性化目标设定，然后进行为期24周的干预维持阶段，以改善结局。对照组仅接收可穿戴身体活动跟踪器。
结论：对小说的需求日益增长，发展适当的干预措施，以增加身体活动并改善儿童癌症的青少年和年轻成年幸存者的健康轨迹。如果有效，这种便携式和可扩展的干预措施将是降低癌症治疗发病率和改善治疗结束后幸存者生活质量的急需工具.
背景：ClinicalTrials.gov标识符：NCT04089358；COG标识符：ALTE2031。
