Abstract：
Drug-Induced Liver Injury (DILI) and herb Induced Liver Injury (HILI) continues to pose a substantial challenge in both clinical practice and drug development, representing a grave threat to patient well-being. This comprehensive review introduces a novel perspective on DILI and HILI by thoroughly exploring the intricate microenvironment of the liver. The dynamic interplay among hepatocytes, sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, cholangiocytes, and the intricate vascular network assumes a central role in drug metabolism and detoxification. Significantly, this microenvironment is emerging as a critical determinant of susceptibility to DILI and HILI. The review delves into the multifaceted interactions within the liver microenvironment, providing valuable insights into the complex mechanisms that underlie DILI and HILI. Furthermore, we discuss potential strategies for mitigating drug-induced liver injury by targeting these influential factors, emphasizing their clinical relevance. By highlighting recent advances and future prospects, our aim is to shed light on the promising avenue of leveraging the liver microenvironment for the prevention and mitigation of DILI and HILI. This deeper understanding is crucial for advancing clinical practices and ensuring patient safety in the realm of DILI and HILI.
摘要：
药物诱导的肝损伤（DILI）和草药诱导的肝损伤（HILI）继续在临床实践和药物开发中构成重大挑战。对病人的健康构成严重威胁.这篇全面的综述通过彻底探索肝脏复杂的微环境，介绍了DILI和HILI的新视角。肝细胞之间的动态相互作用，正弦内皮细胞，Kupffer细胞,肝星状细胞，胆管细胞,复杂的血管网络在药物代谢和解毒中起着核心作用。重要的是,这种微环境正在成为DILI和HILI易感性的关键决定因素。该综述深入研究了肝脏微环境中多方面的相互作用，为DILI和HILI背后的复杂机制提供有价值的见解。此外，我们讨论了通过针对这些影响因素减轻药物性肝损伤的潜在策略，强调其临床相关性。通过强调最新进展和未来前景，我们的目标是阐明利用肝脏微环境预防和缓解DILI和HILI的前景。这种更深入的理解对于在DILI和HILI领域推进临床实践和确保患者安全至关重要。
