Abstract：
Aims/Background: Insulinoma is an extremely rare condition in pediatric patients. This study aims to examine the pathological and clinical characteristics of pediatric insulinoma. Methods: A retrospective, single-center study was conducted involving five pediatric patients diagnosed with insulinoma. The study involved evaluating the postoperative status of the patients during follow-up and analyzing their clinical manifestations, diagnostic work-up, pathological findings, and therapeutic approaches. Results: The study cohort comprised four males and one female, aged between 4 and 9 years. Common symptoms included dizziness and fatigue. The insulinomas were located in various parts of the pancreas: two in the head, one in the neck, one in the body, and one in the tail. After undergoing subtotal pancreatectomy, four patients experienced no side effects during a follow-up period of 41 to 153 months. One patient, who underwent an incomplete pancreatic resection, required ongoing postoperative treatment with 150 mg Creon due to pancreatic enzyme deficiency. Postoperative pathological results indicated that all cases were low-grade neuroendocrine tumours, classified as grade 1 (G1) or grade 2 (G2). Two cases exhibited capsule invasion, and one case showed microvascular invasion. Despite these invasions, no recurrences or metastases have been observed to date. Conclusion: Surgical resection is a viable treatment option for pediatric insulinoma, yielding a favorable prognosis. The presence of capsular and microvascular invasions does not seem to affect the overall prognosis in these cases.
摘要：
目的/背景：胰岛素瘤是儿科患者中极为罕见的疾病。本研究旨在探讨小儿胰岛素瘤的病理和临床特征。方法：回顾性分析，单中心研究纳入5例诊断为胰岛素瘤的儿科患者.该研究包括评估患者在随访期间的术后状况并分析其临床表现。诊断工作,病理结果，和治疗方法。结果：研究队列包括四名男性和一名女性，年龄在4至9岁之间。常见症状包括头晕和疲劳。胰岛素瘤位于胰腺的各个部位：两个在头部，一个在脖子上,一个在身体里，一个在尾巴上。接受胰腺次全切除术后,4例患者在41~153个月的随访期间没有出现副作用.一个病人,接受了不完全胰腺切除术的人，由于胰腺酶缺乏，需要使用150mgCreon进行持续的术后治疗。术后病理显示所有病例均为低度级别神经内分泌肿瘤，分类为1级（G1）或2级（G2）。2例表现为包膜侵犯，1例显示微血管侵犯。尽管有这些入侵,迄今为止没有观察到复发或转移。结论:手术切除是治疗小儿胰岛素瘤的可行选择,预后良好。在这些情况下，包膜和微血管侵入的存在似乎并不影响总体预后。
