PDF(Pubmed)
Abstract：
Dermatomyositis (DM) and polymyositis are idiopathic inflammatory myopathies (IIMs), most associated with solid organ malignancies, and less commonly hematological malignancies. We discuss a case of DM associated with diffuse large B-cell lymphoma, followed by a review of literature on the pathogenesis, clinical course, treatment, and prognosis. Various challenges with the diagnosis and management of underlying lymphoproliferative disorders (LPDs) in patients with IIM are discussed. The case demonstrates the importance of being vigilant of the association between IIM and LPD. Cancer screening in patients with IIM is discussed, including the recently published International Guideline for IIM-Associated Cancer Screening. More research is required to address knowledge gaps in cancer screening in IIM.
摘要：
皮肌炎（DM）和多发性肌炎是特发性炎症性肌病（IIMs），与实体器官恶性肿瘤最相关，和较不常见的血液恶性肿瘤。我们讨论与弥漫性大B细胞淋巴瘤相关的DM病例。随后回顾了有关发病机制的文献，临床课程，治疗,和预后。讨论了IIM患者潜在淋巴增生性疾病（LPDs）的诊断和管理的各种挑战。该案例表明了对IIM和LPD之间关联保持警惕的重要性。讨论了IIM患者的癌症筛查，包括最近出版的IIM相关癌症筛查国际指南。需要更多的研究来解决IIM中癌症筛查的知识空白。
