Abstract：
UNASSIGNED: This study investigated the expression of TGF-β/Smad pathway-related indices in patients with isolated iliac artery aneurysms (IIAA) complicated with iliac arteriovenous fistula (IAVF) and their relationship with prognosis.
UNASSIGNED: From January 2016 to June 2022, 83 patients with IIAA complicated with IAVF (Study group) and 54 patients with IIAA not complicated with IAVF (control group) were studied. The related indices of TGF-β/Smad pathway were evaluated, and the effects of each index on the formation of IAVF were analyzed. The patients were divided into the survival group (64 cases) and death group (19 cases), and the prognostic value of indices in combination was analyzed.
UNASSIGNED: TGF-β, p-Smad2, p-Smad3, p-JNK, and p-ERK in the study group were higher than those in the control group. Abnormal increase of pSmad3 expression was a risk factor for IAVF formation in patients with IIAA. TGF-β level in the death group was higher than that in the survival group, and p-Smad3 and p-JNK proteins were higher than those in the survival group. The AUC value of indices in the TGF-β/Smad pathway in combination was greater than that of each index alone. Abnormal increased expression of pSmad3 was a risk factor for prognosis of patients with IIAA complicated with IAVF.
UNASSIGNED: The abnormal increase of TGF-β/Smad pathway-related indices is related to poor prognosis of patients with IIAA complicated with IAVF, and the combined detection of all indices has a predictive value for patients\' prognosis.
UNASSIGNED: From January 2016 to June 2022, 83 patients with IIAA complicated with IAVF (Study group) and 54 patients with IIAA not complicated with IAVF (control group) were studied. The related indices of TGF-β/Smad pathway were evaluated, and the effects of each index on the formation of IAVF were analyzed. The patients were divided into the survival group (64 cases) and death group (19 cases), and the prognostic value of indices in combination was analyzed.
UNASSIGNED: TGF-β, p-Smad2, p-Smad3, p-JNK, and p-ERK in the study group were higher than those in the control group. Abnormal increase of pSmad3 expression was a risk factor for IAVF formation in patients with IIAA. TGF-β level in the death group was higher than that in the survival group, and p-Smad3 and p-JNK proteins were higher than those in the survival group. The AUC value of indices in the TGF-β/Smad pathway in combination was greater than that of each index alone. Abnormal increased expression of pSmad3 was a risk factor for prognosis of patients with IIAA complicated with IAVF.
UNASSIGNED: The abnormal increase of TGF-β/Smad pathway-related indices is related to poor prognosis of patients with IIAA complicated with IAVF, and the combined detection of all indices has a predictive value for patients\' prognosis.
摘要：
■本研究探讨了TGF-β/Smad通路相关指标在孤立性髂动脉瘤(IIAA)合并髂动静脉瘘(IAVF)患者中的表达及其与预后的关系。
■2016年1月至2022年6月，对83例IIAA合并IAVF患者（研究组）和54例IIAA未合并IAVF患者（对照组）进行研究。评价TGF-β/Smad通路的相关指标,分析了各指标对IAVF形成的影响。将患者分为存活组(64例)和死亡组(19例)。并分析各指标的预后价值。
■TGF-β，p-Smad2,p-Smad3,p-JNK,研究组p-ERK高于对照组。pSmad3表达异常增加是IIAA患者IAVF形成的危险因素。死亡组TGF-β水平高于存活组,p-Smad3和p-JNK蛋白高于存活组。TGF-β/Smad途径联合指标的AUC值大于单独各指标的AUC值。pSmad3表达异常增高是影响IIAA合并IAVF患者预后的危险因素。
■TGF-β/Smad通路相关指标异常升高与IIAA合并IAVF患者预后不良有关，所有指标的联合检测对患者预后有预测价值。
■2016年1月至2022年6月，对83例IIAA合并IAVF患者（研究组）和54例IIAA未合并IAVF患者（对照组）进行研究。评价TGF-β/Smad通路的相关指标,分析了各指标对IAVF形成的影响。将患者分为存活组(64例)和死亡组(19例)。并分析各指标的预后价值。
■TGF-β，p-Smad2,p-Smad3,p-JNK,研究组p-ERK高于对照组。pSmad3表达异常增加是IIAA患者IAVF形成的危险因素。死亡组TGF-β水平高于存活组,p-Smad3和p-JNK蛋白高于存活组。TGF-β/Smad途径联合指标的AUC值大于单独各指标的AUC值。pSmad3表达异常增高是影响IIAA合并IAVF患者预后的危险因素。
■TGF-β/Smad通路相关指标异常升高与IIAA合并IAVF患者预后不良有关，所有指标的联合检测对患者预后有预测价值。
