PDF(Pubmed)
Abstract：
Aortic aneurysms are life-threatening vascular diseases associated with high morbidity, and usually require prophylactic surgical intervention. Current preventative management of aortic aneurysms relies on the diameter and other anatomic parameters of the aorta, but these have been demonstrated to be insufficient predictive factors of disease progression and potential complications. Studies on pathophysiology of aortic aneurysms could fill this need, which already indicated the significance of specific molecules in aortic aneurysms. These molecules provide more accurate prediction, and they also serve as therapeutic targets, some of which are in preclinical stage. In this review, we summarized the inadequacies and achievements of current clinical prediction standards, discussed the molecular targets in prediction and treatment, and especially emphasized the molecules that have shown potentials in early diagnosis, accurate risk assessment and target treatment of aortic aneurysm at early stage.
摘要：
主动脉瘤是危及生命的血管疾病，发病率高，通常需要预防性手术干预。目前主动脉瘤的预防性管理依赖于主动脉的直径和其他解剖参数。但已证明这些因素不足以预测疾病进展和潜在并发症.主动脉瘤的病理生理学研究可以满足这一需求，这已经表明了特定分子在主动脉瘤中的重要性。这些分子提供了更准确的预测，它们也可以作为治疗靶点，其中一些处于临床前阶段。在这次审查中,总结了目前临床预测标准的不足和取得的成绩,讨论了预测和治疗中的分子靶标，特别强调了在早期诊断中显示出潜力的分子，主动脉瘤的早期准确的风险评估和目标治疗。
