PDF(Pubmed)
Abstract：
UNASSIGNED: Carotid-femoral pulse wave velocity (cfPWV) and ejection duration (ED) have different impacts on target organ damage (TOD). The aim of this study was to determine the relationship of cfPWV and ED with TOD.
UNASSIGNED: A total of 1254 patients (64.27% males) from Ruijin Hospital were enrolled in this study from December 2018 to August 2022. Medical records, blood samples and urine samples were collected. The cfPWV was measured and ED was generated using SphygmoCor software (version 8.0, AtCor Medical, Sydney, Australia). TOD including left ventricular hypertrophy (LVH), microalbuminuria, chronic kidney disease (CKD), and abnormality of carotid intima-media thickness (CIMT) were evaluated.
UNASSIGNED: Multiple stepwise linear regression models of cfPWV and ED (individually or together) showed that cfPWV was positively correlated with left ventricular mass index (LVMI) ( β = 0.131, p = 0.002) and Log (albumin-creatinine ratio, ACR) ( β = 0.123, p = 0.004), while ED was negatively correlated with LVMI ( β = -0.244, p < 0.001) and positively correlated with the estimated glomerular filtration rate (eGFR) ( β = 0.115, p = 0.003). When cfPWV and ED were added separately or together in multiple stepwise logistic regression models, cfPWV was associated with CKD [odds ratio (OR) = 1.240, 95% confidence interval (CI) 1.055-1.458, p = 0.009], while ED was associated with LVH (OR = 0.983, 95% CI 0.975-0.992, p < 0.001). In the control group with normal cfPWV and normal ED, LVH was significantly lower in patients with high ED (OR = 0.574, 95% CI 0.374-0.882, p = 0.011), but significantly elevated in those with high cfPWV and low ED (OR = 6.799, 95% CI 1.305-35.427, p = 0.023).
UNASSIGNED: cfPWV was more strongly associated with renal damage, while ED was more strongly associated with cardiac dysfunction. cfPWV and ED affect each other, and together have an effect on LVH.
UNASSIGNED: A total of 1254 patients (64.27% males) from Ruijin Hospital were enrolled in this study from December 2018 to August 2022. Medical records, blood samples and urine samples were collected. The cfPWV was measured and ED was generated using SphygmoCor software (version 8.0, AtCor Medical, Sydney, Australia). TOD including left ventricular hypertrophy (LVH), microalbuminuria, chronic kidney disease (CKD), and abnormality of carotid intima-media thickness (CIMT) were evaluated.
UNASSIGNED: Multiple stepwise linear regression models of cfPWV and ED (individually or together) showed that cfPWV was positively correlated with left ventricular mass index (LVMI) ( β = 0.131, p = 0.002) and Log (albumin-creatinine ratio, ACR) ( β = 0.123, p = 0.004), while ED was negatively correlated with LVMI ( β = -0.244, p < 0.001) and positively correlated with the estimated glomerular filtration rate (eGFR) ( β = 0.115, p = 0.003). When cfPWV and ED were added separately or together in multiple stepwise logistic regression models, cfPWV was associated with CKD [odds ratio (OR) = 1.240, 95% confidence interval (CI) 1.055-1.458, p = 0.009], while ED was associated with LVH (OR = 0.983, 95% CI 0.975-0.992, p < 0.001). In the control group with normal cfPWV and normal ED, LVH was significantly lower in patients with high ED (OR = 0.574, 95% CI 0.374-0.882, p = 0.011), but significantly elevated in those with high cfPWV and low ED (OR = 6.799, 95% CI 1.305-35.427, p = 0.023).
UNASSIGNED: cfPWV was more strongly associated with renal damage, while ED was more strongly associated with cardiac dysfunction. cfPWV and ED affect each other, and together have an effect on LVH.
摘要：
■颈动脉-股动脉脉搏波速度（cfPWV）和射血持续时间（ED）对靶器官损伤（TOD）有不同的影响。本研究的目的是确定cfPWV和ED与TOD的关系。
■2018年12月至2022年8月，瑞金医院共1254例患者（男性占64.27%）纳入本研究。医疗记录,收集血样和尿样。使用SphygmoCor软件（8.0版，AtCorMedical，悉尼,澳大利亚)。TOD包括左心室肥厚（LVH），微量白蛋白尿,慢性肾脏病（CKD），评估颈动脉内中膜厚度（CIMT）的异常。
■cfPWV和ED（单独或一起）的多个逐步线性回归模型显示，cfPWV与左心室质量指数（LVMI）（β=0.131，p=0.002）和Log（白蛋白-肌酐比，ACR）（β=0.123，p=0.004），而ED与LVMI呈负相关(β=-0.244,p<0.001),与估计肾小球滤过率(eGFR)呈正相关(β=0.115,p=0.003)。当cfPWV和ED分别或一起添加到多元逐步逻辑回归模型中时，cfPWV与CKD相关[比值比（OR）=1.240，95％置信区间（CI）1.055-1.458，p=0.009]，而ED与LVH相关(OR=0.983,95%CI0.975-0.992,p<0.001)。在cfPWV正常和ED正常的对照组中，高ED患者LVH显著降低(OR=0.574,95%CI0.374-0.882,p=0.011),但在高cfPWV和低ED的人群中显著升高(OR=6.799，95%CI1.305-35.427，p=0.023)。
■cfPWV与肾损害的相关性更强，而ED与心功能障碍的相关性更强。cfPWV和ED相互影响，一起对LVH有影响。
■2018年12月至2022年8月，瑞金医院共1254例患者（男性占64.27%）纳入本研究。医疗记录,收集血样和尿样。使用SphygmoCor软件（8.0版，AtCorMedical，悉尼,澳大利亚)。TOD包括左心室肥厚（LVH），微量白蛋白尿,慢性肾脏病（CKD），评估颈动脉内中膜厚度（CIMT）的异常。
■cfPWV和ED（单独或一起）的多个逐步线性回归模型显示，cfPWV与左心室质量指数（LVMI）（β=0.131，p=0.002）和Log（白蛋白-肌酐比，ACR）（β=0.123，p=0.004），而ED与LVMI呈负相关(β=-0.244,p<0.001),与估计肾小球滤过率(eGFR)呈正相关(β=0.115,p=0.003)。当cfPWV和ED分别或一起添加到多元逐步逻辑回归模型中时，cfPWV与CKD相关[比值比（OR）=1.240，95％置信区间（CI）1.055-1.458，p=0.009]，而ED与LVH相关(OR=0.983,95%CI0.975-0.992,p<0.001)。在cfPWV正常和ED正常的对照组中，高ED患者LVH显著降低(OR=0.574,95%CI0.374-0.882,p=0.011),但在高cfPWV和低ED的人群中显著升高(OR=6.799，95%CI1.305-35.427，p=0.023)。
■cfPWV与肾损害的相关性更强，而ED与心功能障碍的相关性更强。cfPWV和ED相互影响，一起对LVH有影响。
