PDF(Pubmed)
Abstract：
Discoid lupus erythematosus (DLE) is an autoimmune skin condition that is typically part of the cutaneous manifestation of systemic lupus erythematosus (SLE). DLE is characterized by erythematous patches that can progress to depigmentation and alopecia, leading to scarring and permanent hair loss if left untreated. Herein, we present a unique case of localized DLE on the scalp in a 46-year-old female with no prior history of autoimmune disorders. The patient underwent several medication trials, including intralesional corticosteroids, topical calcineurin inhibitors, topical corticosteroids, and systemic hydroxychloroquine, with limited success in treating her discoid alopecia. Subsequently, a combination therapy of oral hydroxychloroquine and topical pimecrolimus significantly improved her scalp lesion. This case highlights the efficacy of combination therapy in managing localized DLE, providing valuable insights for future research focused on DLE alopecia management and optimizing treatment strategies for similar cases.
摘要：
盘状红斑狼疮（DLE）是一种自身免疫性皮肤病，通常是系统性红斑狼疮（SLE）皮肤表现的一部分。DLE的特点是红斑，可以进展为色素脱失和脱发，如果不及时治疗会导致疤痕和永久性脱发。在这里，我们介绍了1例头皮上局限性DLE的独特病例,该病例是1例46岁女性,既往无自身免疫性疾病史.病人接受了几次药物试验，包括病灶内皮质类固醇,局部钙调磷酸酶抑制剂，外用皮质类固醇,和全身性羟氯喹，治疗她的盘状脱发的成功有限。随后，口服羟氯喹和局部吡美莫司的联合治疗可显着改善她的头皮病变。这个案例强调了联合治疗在管理局部DLE中的功效，为DLE脱发管理和优化类似病例治疗策略的未来研究提供有价值的见解。
