PDF(Pubmed)
Abstract：
Non-cutaneous squamous cell carcinoma (ncSCC) is a rare malignancy, especially involving the orbital and lacrimal apparatus. Hereby, we present a case of recurrence of squamous cell carcinoma (SCC) in the left orbit after excision of lacrimal sac SCC and radiotherapy. She presented with acute painful visual impairment with a frontal headache, with imaging showing medial extraconal and intraconal mass. After confirmation of SCC from the biopsy, modified enucleation was done. However, the patient had a recurrence of SCC, and further debulking was performed with palliative measures. Noteworthy, ncSCC is a rare malignancy with an aggressive nature. Orbital SCC has the worst prognosis compared to conjunctiva or lacrimal sac SCC. Surgery remained the mainstay for higher survival, but chemotherapy and radiotherapy were not associated with a better prognosis, yet there is a lack of data regarding recurrence and its management. In conclusion, ncSCC is a rare and challenging disease that requires timely intervention with multiple disciplinary care, especially when it is spread from the lacrimal sac to the orbital.
摘要：
非皮肤鳞状细胞癌（ncSCC）是一种罕见的恶性肿瘤，特别是涉及眼眶和泪器。特此,我们介绍了一例泪囊SCC切除和放疗后左眼眶鳞状细胞癌（SCC）复发的病例。她出现了急性疼痛性视力障碍和额叶头痛，影像学显示内侧外侧和内侧内肿块。活检证实SCC后，进行了改良摘除。然而,患者出现SCC复发,并采用姑息措施进一步减积。值得注意的是,ncSCC是一种罕见的恶性肿瘤，具有侵袭性。与结膜或泪囊SCC相比，眼眶SCC的预后最差。手术仍然是提高生存率的支柱，但是化疗和放疗与更好的预后无关，然而，缺乏有关复发及其管理的数据。总之,ncSCC是一种罕见且具有挑战性的疾病，需要通过多学科护理及时干预，特别是当它从泪囊扩散到眼眶时。
