PDF(Pubmed)
Abstract：
More than 3 years have passed since the outbreak of COVID-19 and yet, the origin of the causal virus SARS-CoV-2 remains unknown. We examined the evolutionary trajectory of SARS-CoV-2 by analyzing non-redundant genome sets classified based on six closely linked mutations. The results indicated that SARS-CoV-2 emerged in February 2019 or earlier and evolved into three main haplotypes (GL, DS, and DL) before May 2019, which then continued to evolve in parallel. The dominant haplotype GL had spread worldwide in the summer (May to July) of 2019 and then evolved into virulent strains in December 2019 that triggered the global pandemic, whereas haplotypes DL and DS arrived in China in October 2019 and caused the epidemic in China in December 2019. Therefore, haplotype GL neither originated in China nor from the viral strains that caused the epidemic in China. Accordingly, considering data solely from China would be inadequate to reveal the mysterious origin of SARS-CoV-2, emphasizing the necessity of global cooperation.
摘要：
自COVID-19爆发以来已经过去了3年多，致病性病毒SARS-CoV-2的起源仍然未知。我们通过分析基于六个紧密相关突变分类的非冗余基因组集，研究了SARS-CoV-2的进化轨迹。结果表明，SARS-CoV-2在2019年2月或更早出现，并演变为三种主要单倍型（GL，DS,和DL）在2019年5月之前，然后继续并行发展。显性单倍型GL在2019年夏季（5月至7月）在全球范围内传播，然后在2019年12月演变成毒株，引发了全球大流行。而单倍型DL和DS于2019年10月到达中国，并于2019年12月在中国流行。因此,单倍型GL既不起源于中国，也不来自引起中国流行的病毒株。因此，仅考虑来自中国的数据将不足以揭示SARS-CoV-2的神秘起源，强调全球合作的必要性。
