PDF(Pubmed)
Abstract：
Cardiovascular dysfunction induced by sepsis is one of the most common phenotypes of cardiovascular diseases (CVDs), which is closely related to the high mortality of sepsis and is an urgent health problem to be solved worldwide. Unfortunately, the exact pathogenesis and pathophysiology of sepsis-induced cardiovascular dysfunction are not clear. As a research hotspot in recent years, competing endogenous RNA (ceRNA) networks are involved in the modulation of the pathophysiological progression of many diseases, including sepsis-related CVDs. Both long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) can specifically bind to microRNAs (miRNAs) as ceRNAs to target messenger RNAs (mRNAs), forming a ceRNA network composed of lncRNA/circRNA-miRNA-mRNA. This review demonstrates the potential regulatory mechanism of the ceRNA networks in sepsis-induced cardiovascular toxicity, hoping to provide novel therapeutic strategies and monitoring targets for sepsis-related CVDs.
摘要：
脓毒症引起的心血管功能障碍是心血管疾病(CVDs)最常见的表型之一。这与脓毒症的高死亡率密切相关,是全球亟待解决的健康问题。不幸的是,脓毒症引起的心血管功能障碍的确切发病机制和病理生理学尚不清楚。作为近年来的研究热点,竞争内源性RNA（ceRNA）网络参与许多疾病的病理生理进程的调节，包括脓毒症相关的CVD。长链非编码RNA（lncRNAs）和环状RNA（circRNAs）都可以特异性结合microRNAs（miRNAs）作为ceRNAs靶向信使RNA（mRNAs），形成由lncRNA/circRNA-miRNA-mRNA组成的ceRNA网络。这篇综述展示了ceRNA网络在脓毒症诱导的心血管毒性中的潜在调控机制。希望为脓毒症相关CVDs提供新的治疗策略和监测靶点。
