PDF(Pubmed)
Abstract：
UNASSIGNED: Serum uric acid (SUA) levels has been considered a possible risk factor for coronary artery disease (CAD) for many years. Since SUA levels are greatly affected by medications, diet, and metabolism, the association between SUA and CAD has been controversial for centuries. While, the state of hyperuricemia (HUA) has been proven to have a negative impact on CAD in previous studies, there are still few clinical and epidemiological studies of HUA in CAD. In particular, evidence of this association is limited in postmenopausal women. This study explored the influence of SUA levels and HUA on CAD in this demographic group.
UNASSIGNED: In total, 5435 postmenopausal women were allocated to either a non-CAD group (n = 2021) or a CAD group (n = 3414). Regression analyses, including generalized linear models (GLM), correlation analysis, comparison between stratified groups, and analysis by use of diuretics were carried out on data obtained in this study.
UNASSIGNED: SUA and HUA were found to associate significantly with CAD by univariate logistic regression analysis. In addition, GLM showed nonlinear response of CAD probability with increasing level of SUA. In multivariate analysis, we found that SUA and HUA were independently related to CAD. Correlation analysis showed that SUA and HUA both correlated positively with CAD (p < 0.001). By comparing the stratified age groups, we found that the differences among the age groups were significant (p < 0.05).
UNASSIGNED: SUA and HUA were shown to be independently associated with CAD among postmenopausal women.
UNASSIGNED: In total, 5435 postmenopausal women were allocated to either a non-CAD group (n = 2021) or a CAD group (n = 3414). Regression analyses, including generalized linear models (GLM), correlation analysis, comparison between stratified groups, and analysis by use of diuretics were carried out on data obtained in this study.
UNASSIGNED: SUA and HUA were found to associate significantly with CAD by univariate logistic regression analysis. In addition, GLM showed nonlinear response of CAD probability with increasing level of SUA. In multivariate analysis, we found that SUA and HUA were independently related to CAD. Correlation analysis showed that SUA and HUA both correlated positively with CAD (p < 0.001). By comparing the stratified age groups, we found that the differences among the age groups were significant (p < 0.05).
UNASSIGNED: SUA and HUA were shown to be independently associated with CAD among postmenopausal women.
摘要：
■多年来，血清尿酸（SUA）水平一直被认为是冠状动脉疾病（CAD）的可能危险因素。由于SUA水平受到药物的极大影响，饮食，和新陈代谢，SUA和CAD之间的联系几个世纪以来一直存在争议。同时,在先前的研究中，高尿酸血症（HUA）的状态已被证明对CAD有负面影响，HUA在CAD中的临床和流行病学研究仍然很少。特别是,这种关联的证据在绝经后妇女中有限.本研究探讨了SUA水平和HUA对该人群CAD的影响。
■总共，5435名绝经后妇女被分配到非CAD组（n=2021）或CAD组（n=3414）。回归分析，包括广义线性模型(GLM)，相关分析，分层组之间的比较，并对本研究中获得的数据进行了利尿剂使用分析。
■通过单因素逻辑回归分析发现SUA和HUA与CAD显著相关。此外,随着SUA水平的增加，GLM显示CAD概率的非线性响应。在多变量分析中，我们发现SUA和HUA与CAD独立相关。相关性分析显示SUA和HUA均与CAD呈正相关(p<0.001)。通过比较分层的年龄组，我们发现，年龄组之间的差异是显著的（p<0.05）。
■SUA和HUA在绝经后妇女中显示与CAD独立相关。
■总共，5435名绝经后妇女被分配到非CAD组（n=2021）或CAD组（n=3414）。回归分析，包括广义线性模型(GLM)，相关分析，分层组之间的比较，并对本研究中获得的数据进行了利尿剂使用分析。
■通过单因素逻辑回归分析发现SUA和HUA与CAD显著相关。此外,随着SUA水平的增加，GLM显示CAD概率的非线性响应。在多变量分析中，我们发现SUA和HUA与CAD独立相关。相关性分析显示SUA和HUA均与CAD呈正相关(p<0.001)。通过比较分层的年龄组，我们发现，年龄组之间的差异是显著的（p<0.05）。
■SUA和HUA在绝经后妇女中显示与CAD独立相关。
