PDF(Pubmed)
Abstract：
UNASSIGNED: We aim to examine the relationship between age at menarche and hyperhomocysteinemia in women in Hunan Province.
UNASSIGNED: Participants were required to complete a questionnaire that included age at menarche, lifestyle habits, other baseline information, and blood biochemical parameters in a cross-sectional study. The association between hyperhomocysteinemia and age at menarche was examined by Multivariable adjusted logistic regression.
UNASSIGNED: A cohort of 2008 women with a mean age of 60.11 years (aged from 18.0 to 88.0 years) was included in this study. After adjustment for confounding factors such as age, the results showed that the risk of hyperhomocysteinemia among women whose age at menarche were over 16 years was 2.543 (1.849, 3.469) times higher than the risk among women whose age at atmenarche were less than 14 years, and 2.656 (1.882, 3.748) times more likely to have hypertension than women with menarche at 14 years. Besides, the odds ratios of diabetes, hyperlipidemia, and obesity were elevated in women older than 16 years of age at menarche (OR = 1.924, p < 0.001; OR = 1.491, p = 0.014; OR = 1.670, p = 0.022).
UNASSIGNED: Our findings suggest that late menarche tends to be associated with a high risk of hyperhomocysteinemia and its associated set of diseases such as hypertension, diabetes, hyperlipidemia, and obesity in women in Hunan, China. This association tends to differ across birth cohorts. Therefore, adequate attention of menarcheal age may be able to predict diseases in elderly females.
UNASSIGNED: Participants were required to complete a questionnaire that included age at menarche, lifestyle habits, other baseline information, and blood biochemical parameters in a cross-sectional study. The association between hyperhomocysteinemia and age at menarche was examined by Multivariable adjusted logistic regression.
UNASSIGNED: A cohort of 2008 women with a mean age of 60.11 years (aged from 18.0 to 88.0 years) was included in this study. After adjustment for confounding factors such as age, the results showed that the risk of hyperhomocysteinemia among women whose age at menarche were over 16 years was 2.543 (1.849, 3.469) times higher than the risk among women whose age at atmenarche were less than 14 years, and 2.656 (1.882, 3.748) times more likely to have hypertension than women with menarche at 14 years. Besides, the odds ratios of diabetes, hyperlipidemia, and obesity were elevated in women older than 16 years of age at menarche (OR = 1.924, p < 0.001; OR = 1.491, p = 0.014; OR = 1.670, p = 0.022).
UNASSIGNED: Our findings suggest that late menarche tends to be associated with a high risk of hyperhomocysteinemia and its associated set of diseases such as hypertension, diabetes, hyperlipidemia, and obesity in women in Hunan, China. This association tends to differ across birth cohorts. Therefore, adequate attention of menarcheal age may be able to predict diseases in elderly females.
摘要：
■我们旨在研究湖南省女性月经初潮年龄与高同型半胱氨酸血症之间的关系。
■参与者被要求填写包括初潮年龄的问卷，生活习惯,其他基线信息，和血液生化指标的横断面研究。高同型半胱氨酸血症与初潮年龄之间的关系通过多变量调整逻辑回归分析。
■这项研究纳入了2008年平均年龄为60.11岁（年龄在18.0至88.0岁之间）的女性队列。在调整了年龄等混杂因素后，结果显示，初潮年龄超过16岁的女性患高同型半胱氨酸血症的风险是初潮年龄小于14岁的女性患高同型半胱氨酸血症的风险的2.543倍(1.849,3.469)，和2.656（1.882，3.748）倍于女性初潮14岁时患高血压的可能性。此外,糖尿病的优势比，高脂血症,16岁以上女性初潮时肥胖升高(OR=1.924,p<0.001;OR=1.491,p=0.014;OR=1.670,p=0.022).
■我们的研究结果表明，初潮晚期倾向于与高同型半胱氨酸血症及其相关疾病如高血压的高风险相关，糖尿病,高脂血症,湖南女性肥胖，中国。这种关联在出生队列中往往有所不同。因此,充分注意月经初潮年龄可能能够预测老年女性的疾病。
■参与者被要求填写包括初潮年龄的问卷，生活习惯,其他基线信息，和血液生化指标的横断面研究。高同型半胱氨酸血症与初潮年龄之间的关系通过多变量调整逻辑回归分析。
■这项研究纳入了2008年平均年龄为60.11岁（年龄在18.0至88.0岁之间）的女性队列。在调整了年龄等混杂因素后，结果显示，初潮年龄超过16岁的女性患高同型半胱氨酸血症的风险是初潮年龄小于14岁的女性患高同型半胱氨酸血症的风险的2.543倍(1.849,3.469)，和2.656（1.882，3.748）倍于女性初潮14岁时患高血压的可能性。此外,糖尿病的优势比，高脂血症,16岁以上女性初潮时肥胖升高(OR=1.924,p<0.001;OR=1.491,p=0.014;OR=1.670,p=0.022).
■我们的研究结果表明，初潮晚期倾向于与高同型半胱氨酸血症及其相关疾病如高血压的高风险相关，糖尿病,高脂血症,湖南女性肥胖，中国。这种关联在出生队列中往往有所不同。因此,充分注意月经初潮年龄可能能够预测老年女性的疾病。
