PDF(Pubmed)
Abstract：
Sudden cardiac death (SCD) is responsible for approximately 6% of global mortality and 25% of cardiovascular (CV) deaths. SCD has been traditionally linked to coronary artery disease, valvular heart disease, cardiomyopathies, and genetic arrhythmia disorders. However, advancements in care for these diseases have not translated to a proportional reduction in SCD. This suggests an important role of underrecognized contributing pathologies. Neglected tropical diseases (NTDs) are a group of illnesses prevalent in tropical and sub-tropical regions which have been understudied partially due to their high prevalence in marginalized populations. The relationship between SCD and Chagas disease has been well-established, though emerging literature suggests that other NTDs with CV involvement may lead to fatal arrhythmias. Additionally, specific therapies for a subset of NTDs put patients at increased risk of malignant arrhythmias and other cardiac complications. This review aims to summarize the association between a group of selected NTDs and SCD.
摘要：
心脏猝死（SCD）约占全球死亡率的6％，占心血管（CV）死亡的25％。传统上SCD与冠状动脉疾病有关，心脏瓣膜病,心肌病,和遗传性心律失常.然而,这些疾病的治疗进展并未转化为SCD的成比例减少.这表明未被认可的贡献病理的重要作用。被忽视的热带病（NTD）是热带和亚热带地区普遍存在的一组疾病，部分原因是其在边缘化人群中的高患病率，因此尚未得到充分研究。SCD和恰加斯病之间的关系已经很好地确定，尽管新出现的文献表明，其他有CV参与的NTDs可能导致致命的心律失常。此外,针对NTDs亚组的特定治疗使患者发生恶性心律失常和其他心脏并发症的风险增加.这篇综述旨在总结一组选定的NTDs与SCD之间的关联。
