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Abstract：
UNASSIGNED: Recent studies have shown that an increased number of axillary lymph node metastases is associated with non-visualized lymph nodes. The purpose of the study was to retrospectively analyze the incidence and characteristics of non-visualized sentinel lymph nodes (SLNs) in nodal metastases in breast cancer patients.
UNASSIGNED: Consecutive women with breast cancer referred for lymphoscintigraphy from January 2021 to November 2022 were reviewed retrospectively. Findings from resected SLNs and non-SLNs and relevant histopathology were collected and analyzed.
UNASSIGNED: 500 patients diagnosed with breast cancer were reviewed, excluding 93 patients due to neoadjuvant therapy, DCIS, recurrence, or incomplete clinical documentation. Of the 407 remaining patients, 108 patients were positive for axillary lymph node metastases (24 %) and were the focus of the study. Of this patient cohort, 38 patients (35 %) had non-detected SLNs by intraoperative gamma probe and 43 (40 %) had non-visualized SLNs by lymphoscintigraphy. There was statistically significant difference in primary tumor size (39.8 mm versus 28.9 mm), number of resected (6.9 ± 4.4 versus 4.6 ± 2.4) and positive (3.4 ± 2.2 versus 1.6 ± 1.3) lymph nodes, size (13.8 ± 6.1 mm versus 8.1 ± 4.5 mm), tumor grade and tumor stage between the SLN non-visualized and visualized groups. The multivariate logistic regression analysis showed that only lymph node size and number of lymph nodes resected were independent factors associated with SLN non-visualization.
UNASSIGNED: We reported a high non-visualization rate of SLN in breast cancer patients with pathology-proven positive axillary nodes. The causes of the SLN non-visualization are not well understood and warrants further exploration.
UNASSIGNED: Consecutive women with breast cancer referred for lymphoscintigraphy from January 2021 to November 2022 were reviewed retrospectively. Findings from resected SLNs and non-SLNs and relevant histopathology were collected and analyzed.
UNASSIGNED: 500 patients diagnosed with breast cancer were reviewed, excluding 93 patients due to neoadjuvant therapy, DCIS, recurrence, or incomplete clinical documentation. Of the 407 remaining patients, 108 patients were positive for axillary lymph node metastases (24 %) and were the focus of the study. Of this patient cohort, 38 patients (35 %) had non-detected SLNs by intraoperative gamma probe and 43 (40 %) had non-visualized SLNs by lymphoscintigraphy. There was statistically significant difference in primary tumor size (39.8 mm versus 28.9 mm), number of resected (6.9 ± 4.4 versus 4.6 ± 2.4) and positive (3.4 ± 2.2 versus 1.6 ± 1.3) lymph nodes, size (13.8 ± 6.1 mm versus 8.1 ± 4.5 mm), tumor grade and tumor stage between the SLN non-visualized and visualized groups. The multivariate logistic regression analysis showed that only lymph node size and number of lymph nodes resected were independent factors associated with SLN non-visualization.
UNASSIGNED: We reported a high non-visualization rate of SLN in breast cancer patients with pathology-proven positive axillary nodes. The causes of the SLN non-visualization are not well understood and warrants further exploration.
摘要：
■最近的研究表明，腋窝淋巴结转移的数量增加与无法观察的淋巴结有关。目的回顾性分析乳腺癌患者淋巴结转移中不可见前哨淋巴结(SLN)的发生率及特点。
■对2021年1月至2022年11月连续进行淋巴闪烁显像的乳腺癌患者进行回顾性分析。收集并分析切除的SLN和非SLN的发现以及相关的组织病理学。
■对500例诊断为乳腺癌的患者进行了回顾，排除93例因新辅助治疗的患者，DCIS,复发,或不完整的临床文件。剩下的407名患者中,108例患者腋窝淋巴结转移阳性（24％），是研究的重点。在这个病人队列中，38例患者（35％）的术中伽玛探针未检测到SLN，而43例（40％）的淋巴闪烁显像未显示SLN。原发肿瘤大小差异有统计学意义（39.8mm对28.9mm），切除（6.9±4.4对4.6±2.4）和阳性（3.4±2.2对1.6±1.3）淋巴结的数量，尺寸（13.8±6.1mm与8.1±4.5mm），SLN非可视化组和可视化组之间的肿瘤分级和肿瘤分期。多因素logistic回归分析显示，只有淋巴结大小和切除的淋巴结数目是与SLN不可视化相关的独立因素。
■我们报道了在病理证实为腋窝淋巴结阳性的乳腺癌患者中，SLN的非可视化率很高。SLN非可视化的原因尚不清楚，值得进一步探索。
■对2021年1月至2022年11月连续进行淋巴闪烁显像的乳腺癌患者进行回顾性分析。收集并分析切除的SLN和非SLN的发现以及相关的组织病理学。
■对500例诊断为乳腺癌的患者进行了回顾，排除93例因新辅助治疗的患者，DCIS,复发,或不完整的临床文件。剩下的407名患者中,108例患者腋窝淋巴结转移阳性（24％），是研究的重点。在这个病人队列中，38例患者（35％）的术中伽玛探针未检测到SLN，而43例（40％）的淋巴闪烁显像未显示SLN。原发肿瘤大小差异有统计学意义（39.8mm对28.9mm），切除（6.9±4.4对4.6±2.4）和阳性（3.4±2.2对1.6±1.3）淋巴结的数量，尺寸（13.8±6.1mm与8.1±4.5mm），SLN非可视化组和可视化组之间的肿瘤分级和肿瘤分期。多因素logistic回归分析显示，只有淋巴结大小和切除的淋巴结数目是与SLN不可视化相关的独立因素。
■我们报道了在病理证实为腋窝淋巴结阳性的乳腺癌患者中，SLN的非可视化率很高。SLN非可视化的原因尚不清楚，值得进一步探索。
