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Abstract：
Following long-term hypertension, mechanical stretching and neuroendocrine stimulation, cause multiple heterogeneous cells of the heart to interact, and result in myocardial remodeling with myocardial hypertrophy and fibrosis. The immune system, specifically macrophages, plays a vital role in this process. Macrophages are heterogeneous and plastic. Regulated by factors such as microenvironment and cytokines, polarization can be divided into two main forms: M1/M2, with different polarizations playing different roles in left ventricular structural remodeling associated with hypertension. However, descriptions of macrophage phenotypes in hypertension-induced myocardial hypertrophy models are not completely consistent. This article summarizes the phenotypes of macrophages in several models, aiming to assist researchers in studying macrophage phenotypes in hypertension-induced left ventricular structural remodeling models.
摘要：
长期高血压后，机械拉伸和神经内分泌刺激，导致心脏的多个异质细胞相互作用，并导致心肌重塑，心肌肥厚和纤维化。免疫系统,特别是巨噬细胞，在这个过程中起着至关重要的作用。巨噬细胞是异质的和塑性的。受到微环境和细胞因子等因素的调节，极化可以分为两种主要形式：M1/M2，不同的极化在高血压相关的左心室结构重塑中发挥不同的作用。然而,在高血压诱导的心肌肥大模型中对巨噬细胞表型的描述并不完全一致.本文总结了几种模型中巨噬细胞的表型，旨在帮助研究人员研究高血压诱导的左心室结构重构模型中的巨噬细胞表型。
