PDF(Pubmed)
Abstract：
Bone homeostasis in physiology depends on the balance between bone formation and resorption, and in pathology, this homeostasis is susceptible to disruption by different influences, especially under ageing condition. Gut microbiota has been recognized as a crucial factor in regulating host health. Numerous studies have demonstrated a significant association between gut microbiota and bone metabolism through host-microbiota crosstalk, and gut microbiota is even an important factor in the pathogenesis of bone metabolism-related diseases that cannot be ignored. This review explores the interplay between gut microbiota and bone metabolism, focusing on the roles of gut microbiota in bone ageing and aging-related bone diseases, including osteoporosis, fragility fracture repair, osteoarthritis, and spinal degeneration from different perspectives. The impact of gut microbiota on bone metabolism during aging through modification of endocrinology system, immune system and gut microbiota metabolites are summarized, facilitating a better grasp of the pathogenesis of aging-related bone metabolic diseases. This review offers innovative insights into targeting the gut microbiota for the treatment of bone ageing-related diseases as a clinical therapeutic strategy.
摘要：
生理上的骨稳态取决于骨形成和吸收之间的平衡，在病理学上，这种稳态容易受到不同影响的破坏，尤其是在老化条件下。肠道菌群已被认为是调节宿主健康的关键因素。大量研究表明，通过宿主-微生物群串扰，肠道微生物群和骨代谢之间存在显著关联。肠道菌群甚至是骨代谢相关疾病发病机制中不可忽视的重要因素。这篇综述探讨了肠道菌群与骨代谢之间的相互作用，关注肠道菌群在骨骼老化和与老化相关的骨骼疾病中的作用，包括骨质疏松症,脆性骨折修复,骨关节炎,和脊柱退化从不同的角度。肠道菌群通过内分泌系统修饰对衰老过程中骨代谢的影响，免疫系统和肠道微生物代谢产物，有助于更好地掌握衰老相关骨代谢疾病的发病机制。这篇综述提供了针对肠道微生物群作为临床治疗策略治疗骨骼老化相关疾病的创新见解。
