PDF(Pubmed)
Abstract：
The protective effect of high-density lipoprotein (HDL) on atherosclerosis is well known, and its mechanisms of action has been extensively studied. However, the impact of HDL on heart failure and its mechanisms are still controversial or unknown. The cardioprotective role of HDL may be reflected in its antioxidant, anti-inflammatory, anti-apoptotic, and endothelial function protection. In epidemiological studies, high-density lipoprotein cholesterol (HDL-C) levels have been negatively associated with heart failure (HF). The major protein component of HDL-C is apolipoprotein (Apo) A-I, while paraoxonase-1 (PON-1) is an essential mediator for many protective functions of HDL, and HDL may act through components like (Apo) A-I or PON-1 to delay heart failure progress. HDL can slow heart failure disease progression through parts like (Apo) A-I or PON-1. The potential causality between HDL and heart failure, the role of HDL in the pathogenesis of HF, and its interaction with C-reactive protein (CRP), triglycerides (TG), and monocytes in the process of heart failure have been briefly summarized and discussed in this article. HDL plays an important role in the pathogenesis, progression and treatment of HF.
摘要：
高密度脂蛋白(HDL)对动脉粥样硬化的保护作用是众所周知的,其作用机制已被广泛研究。然而,HDL对心力衰竭的影响及其机制仍存在争议或未知。HDL的心脏保护作用可能体现在其抗氧化、抗炎,抗凋亡，和内皮功能保护。在流行病学研究中,高密度脂蛋白胆固醇（HDL-C）水平与心力衰竭（HF）呈负相关。HDL-C的主要蛋白质成分是载脂蛋白（Apo）A-I，虽然对氧磷酶-1（PON-1）是HDL许多保护功能的必需介质，HDL可能通过（Apo）A-I或PON-1等成分延迟心力衰竭进展。HDL可以通过(Apo)A-I或PON-1等部分减缓心力衰竭疾病的进展。HDL和心力衰竭之间的潜在因果关系，HDL在HF发病机制中的作用，及其与C反应蛋白（CRP）的相互作用，甘油三酯（TG），和单核细胞在心力衰竭过程中的作用进行了简要的总结和讨论。HDL在发病机制中起着重要作用，HF的进展和治疗。
