PDF(Pubmed)
Abstract：
Medullary thyroid carcinoma (MTC) can often have an indolent course despite distant metastatic disease. Additionally, given that metastatic MTC is incurable and systemic therapies have non-negligeable toxicities, localized treatments are often favored in presence of oligo-progressive disease. Transarterial radioembolization (TARE) with yttrium-90 (Y90) has emerged as a safe and efficacious treatment for nonresectable primary and metastatic liver tumors, yet data supporting its use in metastatic MTC are limited. We present the case of a patient with hereditary MTC and large bilobar liver metastases who demonstrated tumor response and resolution of their paraneoplastic diarrhea following TARE with Y90 microspheres.
摘要：
尽管有远处转移的疾病，甲状腺髓样癌（MTC）的病程通常会缓慢。此外,鉴于转移性MTC是无法治愈的，并且全身疗法具有不可忽视的毒性，在存在寡进行性疾病的情况下，局部治疗通常是有利的。钇90（Y90）经动脉放射栓塞（TARE）已成为不可切除的原发性和转移性肝肿瘤的安全有效治疗方法。然而,支持其用于转移性MTC的数据有限.我们介绍了一名遗传性MTC和大型双叶肝转移患者的病例，该患者在使用Y90微球TARE后表现出肿瘤反应和副肿瘤性腹泻的消退。
