PDF(Pubmed)
Abstract：
UNASSIGNED: Growing evidence suggests that concurrent ischaemic stroke (IS) exacerbates the prognosis of patients with dilated cardiomyopathy (DCM) and that this effect may be further influenced by sex. However, the exact effect of sex remains unclear. This study aimed to explore the effects of the relevant risk factors on the prognosis of patients with DCM and concurrent IS. Considering the sex differences in DCM, this study further investigated the impact of concurrent IS on the prognosis of men and women with DCM.
UNASSIGNED: A total of 632 patients with DCM enrolled between 2016 and 2021 were included in this study. Clinical data were obtained from medical records, and all participants were followed up in the outpatient clinic or by telephone for at least 1 year. A Cox proportional hazards model and Kaplan-Meier curves were used to evaluate the effects of concurrent IS on the prognosis of patients with DCM.
UNASSIGNED: Patients with DCM complicated with IS (DCM-IS) had significantly lower cumulative survival rates than patients with DCM without IS (non-IS) (74.6% vs. 84.2%, χ 2 = 6.85, p = 0.009). Additionally, IS was associated with greater risks of death and heart transplantation (HTx) in men (75.8% vs. 85.1%, χ 2 = 5.02, p = 0.025), but not in women (71.0% vs. 81.5%, χ 2 = 1.91, p = 0.167).
UNASSIGNED: This large-scale multicentre prospective cohort study demonstrated a poorer prognosis in patients with concurrent DCM and IS, particularly among men. Patients with DCM should not be overlooked in IS screening, emphasis should be placed on the occurrence of IS in patients with DCM. Early and proactive secondary prevention of cerebrovascular diseases might improve the prognosis of DCM patients. More intervention studies focusing on men with DCM complicated with IS should be prioritised.
UNASSIGNED: A total of 632 patients with DCM enrolled between 2016 and 2021 were included in this study. Clinical data were obtained from medical records, and all participants were followed up in the outpatient clinic or by telephone for at least 1 year. A Cox proportional hazards model and Kaplan-Meier curves were used to evaluate the effects of concurrent IS on the prognosis of patients with DCM.
UNASSIGNED: Patients with DCM complicated with IS (DCM-IS) had significantly lower cumulative survival rates than patients with DCM without IS (non-IS) (74.6% vs. 84.2%, χ 2 = 6.85, p = 0.009). Additionally, IS was associated with greater risks of death and heart transplantation (HTx) in men (75.8% vs. 85.1%, χ 2 = 5.02, p = 0.025), but not in women (71.0% vs. 81.5%, χ 2 = 1.91, p = 0.167).
UNASSIGNED: This large-scale multicentre prospective cohort study demonstrated a poorer prognosis in patients with concurrent DCM and IS, particularly among men. Patients with DCM should not be overlooked in IS screening, emphasis should be placed on the occurrence of IS in patients with DCM. Early and proactive secondary prevention of cerebrovascular diseases might improve the prognosis of DCM patients. More intervention studies focusing on men with DCM complicated with IS should be prioritised.
摘要：
■越来越多的证据表明，并发缺血性卒中（IS）会加重扩张型心肌病（DCM）患者的预后，并且这种影响可能进一步受到性别的影响。然而,性别的确切影响尚不清楚。本研究旨在探讨相关危险因素对DCM合并IS患者预后的影响。考虑到DCM的性别差异，这项研究进一步调查了并发IS对DCM男性和女性预后的影响.
■本研究共纳入2016年至2021年的632例DCM患者。临床数据来自医疗记录，所有参与者在门诊或电话随访至少1年.使用Cox比例风险模型和Kaplan-Meier曲线评估并发IS对DCM患者预后的影响。
■DCM合并IS（DCM-IS）患者的累积生存率明显低于无IS（非IS）的DCM患者（74.6％vs.84.2%,χ2=6.85，p=0.009）。此外,IS与男性死亡和心脏移植（HTx）的风险更大（75.8％vs.85.1%,χ2=5.02，p=0.025)，但不是女性（71.0%vs.81.5%,χ2=1.91，p=0.167）。
■这项大规模多中心前瞻性队列研究表明，合并DCM和IS的患者预后较差，尤其是在男性中。在IS筛查中不应该忽视DCM患者，应重点关注DCM患者IS的发生。早期积极的二级预防可以改善DCM患者的预后。应优先考虑更多针对DCM合并IS的男性的干预研究。
■本研究共纳入2016年至2021年的632例DCM患者。临床数据来自医疗记录，所有参与者在门诊或电话随访至少1年.使用Cox比例风险模型和Kaplan-Meier曲线评估并发IS对DCM患者预后的影响。
■DCM合并IS（DCM-IS）患者的累积生存率明显低于无IS（非IS）的DCM患者（74.6％vs.84.2%,χ2=6.85，p=0.009）。此外,IS与男性死亡和心脏移植（HTx）的风险更大（75.8％vs.85.1%,χ2=5.02，p=0.025)，但不是女性（71.0%vs.81.5%,χ2=1.91，p=0.167）。
■这项大规模多中心前瞻性队列研究表明，合并DCM和IS的患者预后较差，尤其是在男性中。在IS筛查中不应该忽视DCM患者，应重点关注DCM患者IS的发生。早期积极的二级预防可以改善DCM患者的预后。应优先考虑更多针对DCM合并IS的男性的干预研究。
