UNASSIGNED: Twenty survivors treated with anthracyclines for childhood malignancies and a matched control group of 20 healthy subjects were enrolled. Arterial elastance (Ea), end-systolic elastance (Ees), Ea/Ees ratio, as well as three-dimensional (3D) LVAC (assessed by measurement of End Systolic Volume [ESV]/Stroke Volume [SV] ratio) were performed at rest. Endothelial function was evaluated by measurement of flow-mediated dilatation (FMD) of the brachial artery.
UNASSIGNED: 3D SV and 3D ESV/SV ratio resulted respectively significantly lower and higher in CCSs than in controls, while Ea, Ees and Ea/Ees ratio were not different among groups. A positive correlation between 3D ESV/SV ratio and cumulative anthracycline doses, as well as with time after drug exposure were also found. Mean FMD was similar in CCSs and controls (8.45 ± 1.79 versus 9.41 ± 3.41, p = 0.34).
UNASSIGNED: In conclusion, conventional LVAC parameters were not shown to be significantly different between CCSs and controls; however, 3D SV and LVAC were significantly impaired in our population. In these patients, endothelial function was comparable to controls. Larger validation studies are therefore needed.
■纳入20名接受蒽环类药物治疗儿童恶性肿瘤的幸存者和20名健康受试者的匹配对照组。动脉弹性(Ea),收缩末期弹性(Ees),Ea/Ees比率,以及三维(3D)LVAC(通过测量收缩末期体积[ESV]/每搏体积[SV]比率进行评估)在休息时进行。通过测量肱动脉的血流介导的扩张(FMD)来评估内皮功能。
■在CCS中,3DSV和3DESV/SV比率分别显着低于和高于对照组,而Ea,Ees和Ea/Ees比率在各组之间没有差异。3DESV/SV比值与累积蒽环类药物剂量呈正相关,以及药物暴露后的时间也被发现。CCS和对照组的平均FMD相似(8.45±1.79对9.41±3.41,p=0.34)。
■总而言之,常规LVAC参数未显示CCS和对照之间有显著差异;然而,在我们的人群中,3DSV和LVAC明显受损。在这些患者中,内皮功能与对照组相当.因此,需要进行更大规模的验证研究。