Abstract：
OBJECTIVE: To evaluate the effects of bariatric arterial embolization (BAE) on gastric emptying of, and the glycaemic response to, an oral glucose load in an obese canine model with impaired glucose tolerance.
METHODS: Eleven male dogs were fed a high-fat, high-fructose diet for 7 weeks before receiving BAE, which involved selective embolization of the left gastric artery (n = 5; 14.9 ± 0.8 kg), or the sham (n = 6; 12.6 ± 0.8 kg) procedure. Postprocedural body weight was measured weekly for 4 weeks. Prior to and at 4 weeks postprocedure, a glucose solution containing 13C-acetate was administered orally for evaluation of the gastric half-emptying time (T50) and the glycaemic response. The relationship between the changes in the blood glucose area under the curve over the first 60 minutes (AUC0-60min) and the T50 was also assessed.
RESULTS: At 4 weeks postprocedure, BAE reduced body weight (BAE vs. the sham procedure: -5.7% ± 0.9% vs. 3.5% ± 0.9%, P < .001), slowed gastric emptying (T50 at baseline vs. postprocedure: 75.5 ± 2.0 vs. 82.5 ± 1.8 minutes, P = .021 in the BAE group; 73.8 ± 1.8 vs. 74.3 ± 1.9 minutes in the sham group) and lowered the glycaemic response to oral glucose (AUC0-60min at baseline vs. postprocedure: 99.2 ± 13.7 vs. 67.6 ± 9.8 mmol·min/L, P = .043 in the BAE group; 100.2 ± 13.4 vs. 103.9 ± 14.6 mmol·min/L in the sham group). The change in the glucose AUC0-60min correlated inversely with that of the T50 (r = -0.711; P = .014).
CONCLUSIONS: In a canine model with impaired glucose tolerance, BAE, while reducing body weight, slowed gastric emptying and attenuated the glycaemic response to an oral glucose load.
METHODS: Eleven male dogs were fed a high-fat, high-fructose diet for 7 weeks before receiving BAE, which involved selective embolization of the left gastric artery (n = 5; 14.9 ± 0.8 kg), or the sham (n = 6; 12.6 ± 0.8 kg) procedure. Postprocedural body weight was measured weekly for 4 weeks. Prior to and at 4 weeks postprocedure, a glucose solution containing 13C-acetate was administered orally for evaluation of the gastric half-emptying time (T50) and the glycaemic response. The relationship between the changes in the blood glucose area under the curve over the first 60 minutes (AUC0-60min) and the T50 was also assessed.
RESULTS: At 4 weeks postprocedure, BAE reduced body weight (BAE vs. the sham procedure: -5.7% ± 0.9% vs. 3.5% ± 0.9%, P < .001), slowed gastric emptying (T50 at baseline vs. postprocedure: 75.5 ± 2.0 vs. 82.5 ± 1.8 minutes, P = .021 in the BAE group; 73.8 ± 1.8 vs. 74.3 ± 1.9 minutes in the sham group) and lowered the glycaemic response to oral glucose (AUC0-60min at baseline vs. postprocedure: 99.2 ± 13.7 vs. 67.6 ± 9.8 mmol·min/L, P = .043 in the BAE group; 100.2 ± 13.4 vs. 103.9 ± 14.6 mmol·min/L in the sham group). The change in the glucose AUC0-60min correlated inversely with that of the T50 (r = -0.711; P = .014).
CONCLUSIONS: In a canine model with impaired glucose tolerance, BAE, while reducing body weight, slowed gastric emptying and attenuated the glycaemic response to an oral glucose load.
摘要：
目的：评估减肥动脉栓塞（BAE）对胃排空的影响，和血糖反应，糖耐量受损的肥胖犬模型的口服葡萄糖负荷。
方法：11只雄性狗被喂食高脂肪，接受BAE前7周的高果糖饮食，其中涉及左胃动脉的选择性栓塞（n=5；14.9±0.8kg），或假手术（n=6；12.6±0.8kg）。术后每周测量体重,持续4周。术前和术后4周,口服含有13C-乙酸盐的葡萄糖溶液,用于评估胃半排空时间(T50)和血糖反应.还评估了前60分钟(AUC0-60分钟)曲线下血糖面积的变化与T50之间的关系。
结果：术后4周，BAE降低了体重（BAE与假手术：-5.7%±0.9%vs.3.5%±0.9%,P<.001),胃排空减慢（基线时的T50与术后：75.5±2.0vs.82.5±1.8分钟，BAE组P=.021；73.8±1.8vs.假手术组74.3±1.9分钟），并降低了对口服葡萄糖的血糖反应（基线时AUC0-60min与术后：99.2±13.7vs.67.6±9.8mmol·min/L,BAE组P=.043；100.2±13.4vs.假手术组103.9±14.6mmol·min/L)。葡萄糖AUC0-60min的变化与T50的变化成反比(r=-0.711;P=0.014)。
结论：在糖耐量受损的犬模型中，BAE,在减轻体重的同时，减缓胃排空并减弱对口服葡萄糖负荷的血糖反应。
方法：11只雄性狗被喂食高脂肪，接受BAE前7周的高果糖饮食，其中涉及左胃动脉的选择性栓塞（n=5；14.9±0.8kg），或假手术（n=6；12.6±0.8kg）。术后每周测量体重,持续4周。术前和术后4周,口服含有13C-乙酸盐的葡萄糖溶液,用于评估胃半排空时间(T50)和血糖反应.还评估了前60分钟(AUC0-60分钟)曲线下血糖面积的变化与T50之间的关系。
结果：术后4周，BAE降低了体重（BAE与假手术：-5.7%±0.9%vs.3.5%±0.9%,P<.001),胃排空减慢（基线时的T50与术后：75.5±2.0vs.82.5±1.8分钟，BAE组P=.021；73.8±1.8vs.假手术组74.3±1.9分钟），并降低了对口服葡萄糖的血糖反应（基线时AUC0-60min与术后：99.2±13.7vs.67.6±9.8mmol·min/L,BAE组P=.043；100.2±13.4vs.假手术组103.9±14.6mmol·min/L)。葡萄糖AUC0-60min的变化与T50的变化成反比(r=-0.711;P=0.014)。
结论：在糖耐量受损的犬模型中，BAE,在减轻体重的同时，减缓胃排空并减弱对口服葡萄糖负荷的血糖反应。
