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Abstract：
OBJECTIVE: Sexuality is an important dimension of health-related quality of life (HRQOL) in cancer patients. Studies evidence that most patients report impairments of their sexual health related to their disease or its treatment. The Quality of Life Group of the European Organization for the Research and Treatment of Cancer (EORTC) developed a patient reported outcome measure assessing multidimensional aspects of sexual health. The validation study for this instrument revealed heterogenous results for patients in palliative oncological treatment. The aim of this secondary analyses is to examine differences in patient related sexual health outcomes between palliative patients with good performance status (GPS) and those with poor performance status (PPS).
METHODS: In this observational cohort study, self-reported sexual health issue scores were compared between the two groups of patients in palliative oncological treatment with GPS vs PPS status.
RESULTS: Patients with GPS experienced significantly more sexual satisfaction than patients with PPS (p = 0.015). They reported significantly more treatment effects on their sexual activity (p = 0.005) and suffer more from decreased libido (p = 0.008). Patients with PPS reported significantly more fatigue (p = 0.03) and regarded preservation of sexual activity of higher importance than did patients with GPS (p = 0.049).
CONCLUSIONS: Our study demonstrates the importance of sexuality for patients in palliative oncological treatment, especially for those with limited performance status. Considering the patients´ perspective, sexual health reaches beyond physical functioning. Patients in a palliative phase of disease report high levels of psychosexual problems while sexual performance deteriorates. Sexuality is an important aspect of HRQOL for these patients, needs to be addressed by health care providers and sensitively integrated into palliative care plans.
METHODS: In this observational cohort study, self-reported sexual health issue scores were compared between the two groups of patients in palliative oncological treatment with GPS vs PPS status.
RESULTS: Patients with GPS experienced significantly more sexual satisfaction than patients with PPS (p = 0.015). They reported significantly more treatment effects on their sexual activity (p = 0.005) and suffer more from decreased libido (p = 0.008). Patients with PPS reported significantly more fatigue (p = 0.03) and regarded preservation of sexual activity of higher importance than did patients with GPS (p = 0.049).
CONCLUSIONS: Our study demonstrates the importance of sexuality for patients in palliative oncological treatment, especially for those with limited performance status. Considering the patients´ perspective, sexual health reaches beyond physical functioning. Patients in a palliative phase of disease report high levels of psychosexual problems while sexual performance deteriorates. Sexuality is an important aspect of HRQOL for these patients, needs to be addressed by health care providers and sensitively integrated into palliative care plans.
摘要：
目的：性欲是癌症患者健康相关生活质量（HRQOL）的一个重要维度。研究表明，大多数患者报告与疾病或治疗有关的性健康受损。欧洲癌症研究与治疗组织（EORTC）的生活质量小组开发了一种患者报告的结果指标，评估了性健康的多维方面。该仪器的验证研究显示，姑息性肿瘤治疗患者的结果不均匀。此次要分析的目的是检查具有良好表现状态（GPS）的姑息性患者与表现状态较差（PPS）的患者之间与患者相关的性健康结果的差异。
方法：在这项观察性队列研究中，使用GPS和PPS状态比较了两组姑息性肿瘤治疗患者的自我报告性健康问题评分.
结果：GPS患者的性满意度明显高于PPS患者（p=0.015）。他们报告了对他们的性活动的治疗效果明显更多（p=0.005），并且性欲下降（p=0.008）。与GPS患者相比，PPS患者报告的疲劳显着增加（p=0.03），并且认为保留性活动的重要性更高（p=0.049）。
结论：我们的研究表明，在姑息性肿瘤治疗中，性行为对患者的重要性，特别是对于那些有限的性能状态。从病人的角度考虑,性健康超越身体机能。处于疾病姑息期的患者报告高水平的性心理问题，而性表现恶化。性欲是这些患者HRQOL的一个重要方面，需要由医疗保健提供者解决，并敏感地纳入姑息治疗计划。
方法：在这项观察性队列研究中，使用GPS和PPS状态比较了两组姑息性肿瘤治疗患者的自我报告性健康问题评分.
结果：GPS患者的性满意度明显高于PPS患者（p=0.015）。他们报告了对他们的性活动的治疗效果明显更多（p=0.005），并且性欲下降（p=0.008）。与GPS患者相比，PPS患者报告的疲劳显着增加（p=0.03），并且认为保留性活动的重要性更高（p=0.049）。
结论：我们的研究表明，在姑息性肿瘤治疗中，性行为对患者的重要性，特别是对于那些有限的性能状态。从病人的角度考虑,性健康超越身体机能。处于疾病姑息期的患者报告高水平的性心理问题，而性表现恶化。性欲是这些患者HRQOL的一个重要方面，需要由医疗保健提供者解决，并敏感地纳入姑息治疗计划。
