关键词: Disseminated tuberculosis infection Hemophagocytic lymphohistiocytosis Tuberculosis Tuberculous meningitis Urinary retention

Mesh : Humans Male Lymphohistiocytosis, Hemophagocytic / drug therapy diagnosis Aged Meningoencephalitis / drug therapy microbiology complications Antitubercular Agents / therapeutic use Psoas Abscess / microbiology drug therapy Tuberculosis / complications drug therapy Abscess / microbiology drug therapy

来  源:   DOI:10.1186/s12879-024-09661-x   PDF(Pubmed)

Abstract:
BACKGROUND: As disseminated extrapulmonary tuberculosis infection can involve multiple systems and result in atypical clinical manifestations that mimic other diseases, the diagnosis may be difficult, especially in elderly patients. Delaying treatment can adversely affect the prognosis. And to achieve better prognosis, early detection and diagnosis are necessary, as well as early initiation of comprehensive treatment.
METHODS: We present the case of a 78-year-old man with disseminated tuberculosis who developed the uncommon complication of urinary retention due to a psoas abscess, meningoencephalitis, and the rare secondary hemophagocytic lymphohistiocytosis syndrome. The patient achieved a favorable outcome following targeted therapy with antitubercular medications.
CONCLUSIONS: This case highlights that disseminated extrapulmonary tuberculosis infection can present with a variety of manifestations, and may exhibit many rare and complex clinical presentations. Prompt and accurate diagnosis and treatment play a crucial role in improving prognosis for the patients with persistent fever.
摘要:
背景:由于播散性肺外结核感染可累及多个系统,并导致模仿其他疾病的非典型临床表现,诊断可能很困难,尤其是老年患者。延迟治疗会对预后产生不利影响。为了获得更好的预后,早期发现和诊断是必要的,以及早期开始综合治疗。
方法:我们介绍了一名78岁的男性播散性肺结核患者,他由于腰大肌脓肿而出现了罕见的尿潴留并发症,脑膜脑炎,和罕见的继发性噬血细胞性淋巴组织细胞增多症。患者在使用抗结核药物进行靶向治疗后取得了良好的结果。
结论:本病例强调播散性肺外结核感染可表现为多种表现,并可能表现出许多罕见和复杂的临床表现。及时准确的诊断和治疗对改善持续发热患者的预后起着至关重要的作用。
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