PDF(Pubmed)
Abstract：
With distinct advantages in clinical application, total knee arthroplasty (TKA) is an effective surgical option for treating end-stage osteoarthritis in the knee. After TKA, incisional problems are one of the major factors influencing the speed in which patients recover. Although it is widely acknowledged that preoperative hypoalbuminemia and the incidence of incisional complications are significantly associated, it is still unclear if postoperative hypoalbuminemia raises the risk of incisional complications following TKA. Furthermore, human serum albumin (HSA) is frequently utilized domestically and internationally to treat postoperative hypoalbuminemia; nevertheless, there is ongoing discussion on whether HSA supplementation can enhance postoperative clinical outcomes. To investigate the relationship between hypoalbuminemia and suboptimal incision healing following TKA, as well as to determine whether HSA supplementation can enhance incision healing after surgery, we collected clinical data for this study. The study sample consisted of 22 patients with poorly healed incisions and 120 cases with normal healing of incisions who underwent TKA treatment for knee osteoarthritis (KOA) in the operator\'s hospital\'s Department of Orthopaedics between July 1, 2020, and July 1, 2023. To determine the prevalence of postoperative poor incision healing, data on patients\' basic characteristics, preoperative test results, surgical data, postoperative test results, and postoperative incision healing were gathered. The contributing factors to inadequate recovery after surgery were examined using SPSS software. After controlling for confounding variables, a multivariate regression analysis model was used to examine the relationship between postoperative hypoalbuminemia, HSA supplementation, and poor incision healing. 22 cases (15.49%) had poor wound healing following surgery. The findings of multivariate regression analysis after controlling for confounders indicated that there was no correlation between poor wound healing and postoperative albumin level (P > 0.05). Similarly, there was no association (P > 0.05) seen between HSA supplementation and poor incision healing. Following the TKA, postoperative hypoalbuminemia does not raise the risk of incisional problems, and postoperative HSA supplementation neither lowers nor enhances the risk of inadequate incisional healing.
摘要：
在临床应用中具有明显的优势，全膝关节置换术(TKA)是治疗终末期膝关节骨性关节炎的有效手术选择.在TKA之后,切口问题是影响患者康复速度的主要因素之一。尽管人们普遍认为术前低蛋白血症和切口并发症的发生率显著相关，目前尚不清楚术后低蛋白血症是否会增加TKA术后切口并发症的风险.此外，人血清白蛋白（HSA）在国内和国际上经常用于治疗术后低白蛋白血症；然而，目前正在讨论补充HSA是否能提高术后临床结局.探讨TKA术后低蛋白血症与切口愈合不良的关系,以及确定是否补充HSA可以促进手术后的切口愈合，我们收集了本研究的临床数据.研究样本包括22例切口愈合不良的患者和120例切口愈合正常的患者，他们在2020年7月1日至7月1日期间在手术方医院骨科接受了TKA治疗膝骨性关节炎（KOA），2023年。确定术后切口愈合不良的发生率。关于患者基本特征的数据，术前检查结果,手术数据,术后检查结果,术后切口愈合。使用SPSS软件检查了导致手术后恢复不足的因素。在控制了混杂变量之后，多元回归分析模型用于检查术后低蛋白血症之间的关系，HSA补充，切口愈合不良。22例(15.49%)术后伤口愈合不良。控制混杂因素后的多因素回归分析显示,创面愈合不良与术后白蛋白水平无相关性(P>0.05)。同样，HSA补充与切口愈合不良无相关性(P>0.05)。在TKA之后,术后低蛋白血症不会增加切口问题的风险，术后补充HSA既不会降低也不会增加切口愈合不足的风险。
