Abstract：
Fragile X Syndrome (FXS) stands out as a prominent cause of inherited intellectual disability and a prevalent disorder closely linked to autism. FXS is characterized by substantial alterations in social behavior, encompassing social withdrawal, avoidance of eye contact, heightened social anxiety, increased arousal levels, language deficits, and challenges in regulating emotions. Conventional behavioral assessments primarily focus on short-term interactions within controlled settings. In this study, we conducted a comprehensive examination of the adaptive group behavior of Fmr1 KO male mice over a three-day period, without introducing experimental interventions or task-based evaluations. The data unveiled intricate behavioral anomalies, with the most significant changes manifesting during the initial adaptation to unfamiliar environments. Notably, certain behaviors exhibited a gradual return to typical patterns over time. This dynamic Fmr1 KO phenotype exhibited heightened activity, featuring increased exploration, amplified social interest, and an unconventional approach to social interactions characterized by a higher frequency of shorter engagements. These findings contribute to the growing understanding of social behavior in individuals with FXS and underscore the significance of comprehending their adaptive responses in various environmental contexts.
摘要：
脆性X综合征（FXS）是遗传性智力残疾的主要原因，也是与自闭症密切相关的流行疾病。FXS的特点是社会行为发生了实质性的变化，包括社会退缩，避免眼神接触,社交焦虑加剧,提高唤醒水平，语言障碍,以及调节情绪的挑战。传统的行为评估主要集中在受控环境中的短期互动。在这项研究中,我们在三天的时间内对Fmr1KO雄性小鼠的适应性群体行为进行了全面检查，不引入实验性干预措施或基于任务的评估。数据揭示了复杂的行为异常，在对陌生环境的初始适应过程中表现出最显著的变化。值得注意的是,随着时间的推移，某些行为表现出逐渐回归典型模式。这种动态的Fmr1KO表型表现出增强的活性，以增加探索为特征，放大的社会兴趣，以及一种非常规的社交互动方法，其特征是较高频率的较短参与。这些发现有助于人们对FXS个体的社会行为的日益理解，并强调了在各种环境背景下理解他们的适应性反应的重要性。
