一般毛细血管内皮细胞通过 HIF - 2 α / Notch4 通路重编程为肺动脉高压的动脉内皮细胞。
关键词: PAH angiogenesis endothelium lung vasculature right heart failure
Mesh : Basic Helix-Loop-Helix Transcription Factors / metabolism genetics Endothelial Cells / metabolism pathology Hypertension, Pulmonary / metabolism pathology Animals Humans Signal Transduction Receptor, Notch4 / metabolism genetics Cellular Reprogramming Capillaries / metabolism pathology Mice Pulmonary Artery / metabolism pathology cytology
来 源:
DOI:10.1161/CIRCULATIONAHA.123.067981
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