Abstract：
Short-term exposure to air pollution has previously been studied in relation to certain neurological disorders, but there is still a lack of convincing data linking air pollution to epileptic seizures. The study\'s goal was to investigate how exposure to ambient nitrogen dioxide (NO2) affected the number of patients seeking assistance at the Wuhan Emergency Medical Center due to epileptic seizures. We gathered data on medical emergency calls (MECs), daily ambient air pollution concentrations (SO2, NO2, PM2.5, PM10, CO, and O3), and meteorological variables in Wuhan, China, spanning from January 1, 2017, to November 30, 2019. To investigate the potential influence of ambient nitrogen dioxide on MECs for epileptic seizures, we carried out a time-series investigation using the general additive model (GAM). Additionally, analyses stratified by season, age, and gender were performed. A total of 8989 records of MECs for epileptic seizures were enrolled in our study during the period. Statistical analysis indicates that a rise of 10 μg/m3 in NO2 concentration is linked to a 0.17% increase in daily MECs for epileptic seizures (95% confidence interval [CI]: 0.02%, 0.32%). Furthermore, people aged 14-59 years were more susceptible(2.25%, P < 0.05). The short-term effects of NO2 exposure on daily MECs for epileptic seizures were stronger in warm seasons than in cool seasons (0.55% vs. -0.10%, P < 0.0001). Our findings suggests that short-term exposure to ambient NO2 was positively correlated with daily MECs for epileptic seizures in Wuhan, China. Additionally, we observed that these associations were stronger in patients aged above 14 but under 60 years and the warmer seasons (from April to September).
摘要：
先前已经研究了短期暴露于空气污染与某些神经系统疾病的关系，但是仍然缺乏令人信服的数据将空气污染与癫痫发作联系起来。该研究的目的是调查暴露于环境二氧化氮（NO2）如何影响因癫痫发作而在武汉急诊医学中心寻求救助的患者人数。我们收集了医疗急救电话(MEC)的数据，每日环境空气污染浓度(SO2，NO2，PM2.5，PM10，CO，和O3），和武汉的气象变量，中国,从2017年1月1日到2019年11月30日。为了研究环境二氧化氮对癫痫发作的MEC的潜在影响，我们使用一般加法模型(GAM)进行了时间序列调查。此外,按季节分层的分析，年龄,和性别进行了。在此期间，我们的研究共纳入了8989例癫痫发作的MEC记录。统计分析表明，NO2浓度增加10μg/m3与癫痫发作的每日MEC增加0.17％有关（95％置信区间[CI]：0.02％，0.32%）。此外，14-59岁的人更容易受到影响(2.25%，P<0.05)。在温暖的季节，NO2暴露对癫痫发作的每日MEC的短期影响比在凉爽的季节更强（0.55％vs.-0.10%，P<0.0001)。我们的发现表明，在武汉，短期暴露于环境NO2与每日MECs呈正相关，中国。此外,我们观察到,在年龄大于14岁但小于60岁和温暖季节(4月至9月)的患者中,这些相关性更强.
