METHODS: Participants included 998 school-age children aged 7-12 years (514 girls and 484 boys). Metabolite concentrations of four PAHs (1-hydroxypyrene [1-OHPyr], 2-hydroxynaphthalene [2-OHNap], 2-hydroxyfluorine [2-OHFlu], and 9-hydroxyphenanthrene [9-OHPhe]) were measured in urine samples at baseline (Dec 2014-Dec 2015). During adolescence, we measured emotional and behavioral problems in study participants. We used logistic regression models to assess the effects of different levels of PAH metabolite concentrations on emotional and behavioral problems for boys and girls, separately.
RESULTS: Boys exposed to 1-OHPyr and 2-OHFlu had a significantly higher risk of externalizing problems (OR: 2.62, 95% CI: 1.09 ~ 6.29; OR: 2.92, 95% CI: 1.15 ~ 7.42). 2-OHNap exposure faced a higher risk of internalizing problems (OR: 3.85, 95% CI: 1.28 ~ 11.58; OR: 3.63, 95% CI: 1.13 ~ 11.63) and externalizing problems (OR: 4.27, 95% CI: 1.44 ~ 12.70; OR: 4.68, 95% CI: 1.49 ~ 14.73). Moreover, boys exposed to 9-OHPhe exhibited a significant risk of anxiety (OR: 2.84, 95% CI: 1.01 ~ 7.97; OR: 3.00, 95% CI: 1.04 ~ 8.68). Similarly, girls exposed to 9-OHPhe had a significant risk of anxiety (OR: 2.41, 95% CI: 1.25 ~ 4.64).
CONCLUSIONS: Childhood PAH exposures are associated with emotional and behavioral problems in adolescence, and boys seem more susceptible than girls.
方法:参与者包括998名7-12岁的学龄儿童(514名女孩和484名男孩)。四种PAHs的代谢物浓度(1-羟基芘[1-OHPyr],2-羟基萘[2-OHNap],2-羟基氟[2-OHFlu],和9-羟基菲[9-OHP])在基线时(2014年12月至2015年12月)在尿液样本中进行测量。在青春期,我们测量了研究参与者的情绪和行为问题。我们使用逻辑回归模型来评估不同水平的PAH代谢物浓度对男孩和女孩的情绪和行为问题的影响。分开。
结果:暴露于1-OHPyr和2-OHFlu的男孩发生外化问题的风险明显更高(OR:2.62,95%CI:1.09〜6.29;OR:2.92,95%CI:1.15〜7.42)。2-OHNap暴露面临较高的内化问题风险(OR:3.85,95%CI:1.28~11.58;OR:3.63,95%CI:1.13~11.63)和外化问题风险(OR:4.27,95%CI:1.44~12.70;OR:4.68,95%CI:1.49~14.73)。此外,暴露于9-OHP的男孩表现出明显的焦虑风险(OR:2.84,95%CI:1.01〜7.97;OR:3.00,95%CI:1.04〜8.68)。同样,暴露于9-OHP的女孩有明显的焦虑风险(OR:2.41,95%CI:1.25〜4.64)。
结论:儿童PAH暴露与青春期的情绪和行为问题有关,男孩似乎比女孩更容易受到影响。