Abstract：
Left atrium longitudinal strain (LAS) with speckle tracking method has been proposed as a non-invasive method for the assessment of left ventricular filling pressure and diastolic dysfunction. This study aimed to investigate left atrial strain compared to invasively measured left ventricular filling pressure. All Patients candidates for coronary angiography were consecutively recruited. LAS measured by transthoracic echocardiography. Left ventricular end-diastolic pressure (LVEDP) pressure was invasively measured. Current echocardiographic modalities for diastolic function evaluated. A total of 125 people were included. 45 patients had preserved ejection fraction (EF ≥ 50%) and 85 patients had reduced EF (EF < 50%) and compared two groups. LVEDP was significantly higher in reduced EF compared to preserved EF (p-value < 0.001). LA-reservoir and LA-booster strains were significantly lower in patients with reduced EF compared to preserved EF (p-value = 0.008, mean Reservoir = 16.4% ± 6.4, mean Reservoir = 19.5% ± 5.6, respectively) and (p-value = 0.009, mean Booster = 9.09% ± 4.0, mean Booster =11. 9% ± 4.3, respectively). LA 4ch-reservoir strain <14.4%, and LA 2ch-reservoir strain <14.1% were related to LVEDP≥20 mmHg (sensitivity 63.5% and specificity 75%) (sensitivity 77.9% and specificity of 60%) respectively. LAS is significantly lower in patients with elevated LVEDP (≥ 20mmHg). LAS is significantly lower in patients with reduced EF. Both LA-reservoir and LA-booster strains have a significant relation to predicting LVFP but LA-reservoir strain is more accurate. The mean LA-reservoir strain less than 12.4% is associated with LVEDP ≥ 20mmHg.
摘要：
斑点追踪法左心房纵向应变（LAS）已被提出作为评估左心室充盈压和舒张功能障碍的非侵入性方法。这项研究旨在研究与侵入性测量的左心室充盈压相比的左心房应变。连续招募所有冠状动脉造影候选人。经胸超声心动图测量LAS。左心室舒张末期压（LVEDP）压力是有创测量的。评估舒张功能的当前超声心动图模式。总共包括125人。45例患者射血分数保留(EF≥50%),85例患者射血分数降低(EF<50%)。LVEDP在降低的EF中显著高于保留的EF(p值<0.001)。与保留的EF相比，EF降低的患者的LA储库和LA加强菌株显着降低（p值=0.008，平均储库=16.4％±6.4，平均储库=19.5％±5.6）和（p值=0.009，平均助推器=9.09％±4.0，平均助推器=11。分别为9%±4.3)。LA4ch-储层应变<14.4%，LA2ch-储层应变<14.1％与LVEDP≥20mmHg（敏感性为63.5％，特异性为75％）（敏感性为77.9％，特异性为60％）相关。LVEDP升高（≥20mmHg）的患者LAS明显较低。EF降低的患者LAS显著降低。LA储层和LA增强菌株与预测LVFP都有重要关系，但LA储层菌株更准确。平均LA-储层应变小于12.4%与LVEDP≥20mmHg相关。
