METHODS: A literature review was conducted using PubMed/MEDLINE, Scopus, and the Cochrane library until December 2023. Search algorithm was constructed using the following terms and their associated Mesh terms and Boolean operators: \"urinary microbiome\" and \"urinary microbiota\". Studies written in English language, identifying, and comparing urinary microbiome among bladder cancer patients and healthy control group were included in the review.
RESULTS: A total of 2,356 reports were identified. From this total 16 articles complied with the inclusion criteria were selected for analysis. These articles represent a total of about 486 bladder cancer patients.
CONCLUSIONS: Recent studies revealed the colonization of the urinary tract and the bladder by micro-organisms using both enhanced culture- and molecular-based techniques for microbial characterization. However, several limitations exist in the literature decreasing the reliability of the current reports. As a result, urinary microbiome consist an ambitious era in bladder cancer research with an increasing number of evidence about its potential pathogenetic, prognostic and therapeutic role.
方法:使用PubMed/MEDLINE进行了文献综述,Scopus,和Cochrane图书馆直到2023年12月。使用以下术语及其相关的网格术语和布尔运算符构建搜索算法:“尿微生物组”和“尿微生物群”。用英语写的研究,识别,并比较膀胱癌患者和健康对照组的尿液微生物组。
结果:共确认2,356份报告。从中选择符合纳入标准的16篇文章进行分析。这些文章代表总共约486名膀胱癌患者。
结论:最近的研究表明,使用增强的基于培养和分子的微生物表征技术,微生物在泌尿道和膀胱中定植。然而,文献中存在一些限制,降低了当前报告的可靠性。因此,尿微生物组包括一个雄心勃勃的时代在膀胱癌的研究与越来越多的证据关于其潜在的致病性,预后和治疗作用。