Abstract：
Increasing evidence implicates compromised myelin integrity and oligodendrocyte abnormalities in the dysfunction of neuronal networks in schizophrenia. We previously reported a deficiency of myelinating oligodendrocytes (OL), oligodendrocyte progenitors (OP) and satellite oligodendrocytes of neurons (Sat-OL) in the prefrontal cortex and the inferior parietal cortex - cortical hubs of the frontoparietal cognitive network and default mode network (DMN) altered in schizophrenia. Deficiency of OL and OP was also detected in the head of the caudate nucleus (HCN), which accumulates cortical projections from the associative cortex and is the central node of these networks. However, the number of Sat-Ol per neuron in schizophrenia has not been studied in the HCN. In the current study we estimated the number of Sat-Ol per neuron in the rostral part of the HCN in schizophrenia (n = 18) compared to healthy controls (n = 18) in the same section collection that was previously used to study the number Ol and OP. We found a significant decrease of the number of Sat-Ol per neuron (- 50%, p < 0.001) in schizophrenia as compared to normal controls. Considering that the rostral part of the HCN is an individual network-specific projection zone of the DMN, the deficit of Sat-Ol found in schizophrenia may be related to the dysfunctional DMN-HCN connections, which has been repeatedly described in schizophrenia. The dramatic decrease of the number of Sat-Ol per neuron may be partially related to a pronounced excess of dopamine concentration in the rostral part of the HCN in schizophrenia.
摘要：
越来越多的证据表明，精神分裂症的神经元网络功能障碍中的髓磷脂完整性受损和少突胶质细胞异常。我们以前报道了髓鞘少突胶质细胞（OL）的缺乏，前额叶皮层和下顶叶皮层中的少突胶质细胞祖细胞（OP）和神经元的卫星少突胶质细胞（Sat-OL）-精神分裂症中额顶认知网络和默认模式网络（DMN）的皮质中心发生了改变。在尾状核（HCN）的头部也检测到OL和OP的缺乏，它积累了来自联想皮层的皮层投影，是这些网络的中心节点。然而,在HCN中尚未研究精神分裂症中每个神经元的Sat-Ol数量。在本研究中,我们估计了精神分裂症(n=18)中HCN的延髓部分中每个神经元的Sat-Ol的数量,与先前用于研究数量Ol和OP的相同切片集合中的健康对照(n=18)相比。我们发现每个神经元的Sat-Ol数量显着减少（-50％，与正常对照相比，精神分裂症中的p<0.001）。考虑到HCN的主要部分是DMN的单个网络特定投影区，在精神分裂症中发现的Sat-Ol缺陷可能与功能失调的DMN-HCN连接有关，这在精神分裂症中被反复描述。每个神经元的Sat-Ol数量的急剧减少可能与精神分裂症中HCN的前端部分中多巴胺浓度的明显过量有关。
