METHODS: CwCF who underwent otorhinolaryngologic and audiologic examinations were retrospectively included. Clinical characteristics, ear-nose-throat related symptoms, and a history of ototoxic drug exposure were recorded. m.1555A>G mutations were retrospectively screened among patients with audiologic evaluations.
RESULTS: Two hundred thirty-four cwCF were included in this study with a median age of 10.7 (range, 6.8-14.2) years. Nasal obstruction (14.1%) was the most common symptom. Fifty-two (22.2%) patients had chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP). There was a positive correlation between CRSwNP and the symptom of nasal obstruction (r:.234, p < .001), snoring (r:.179, p = .006), and sleeping with mouth open (r:.138, p = .034). One hundred forty-nine (63.6%) patients had audiologic evaluations; 14 (9.4%) had hearing impairment. No statistical significance existed between ototoxicity and IV AG exposure (p = .90). Six (42.8%) of 14 patients did not receive ototoxic drugs. One hundred nineteen (50.8%) patients were screened for m.1555A>G mutations, and none were detected.
CONCLUSIONS: Almost a quarter of the study population had CRSwNP. Neither the relationship between AGs exposure and hearing loss nor the genetic predisposition to AG ototoxicity could be shown in cwCF.
方法:回顾性纳入接受耳鼻喉和听力学检查的CwCF。临床特征,耳鼻喉相关症状,并记录耳毒性药物暴露史.在听力学评估的患者中回顾性筛查m.155A>G突变。
结果:这项研究包括了2334个cwCF,中位年龄为10.7岁(范围,6.8-14.2)年。鼻塞(14.1%)是最常见的症状。52例(22.2%)患者患有慢性鼻-鼻窦炎(CRS)伴鼻息肉(CRSwNP)。CRSwNP与鼻塞症状呈正相关(r:.234,p<.001),打鼾(r:.179,p=.006),张开嘴睡觉(r:.138,p=.034)。一百四十九名(63.6%)患者进行了听力学评估;14(9.4%)有听力障碍。耳毒性和IVAG暴露之间无统计学意义(p=.90)。14例患者中有6例(42.8%)未接受耳毒性药物。一百十九名(50.8%)患者进行了m.155A>G突变筛查,没有人被发现。
结论:几乎四分之一的研究人群患有CRSwNP。在cwCF中既不能显示AG暴露与听力损失之间的关系,也不能显示AG耳毒性的遗传易感性。