OBJECTIVE: This review aims to summarize the interaction between the gut microbiota and TLR signaling pathways and to enumerate the role of microbiota dysbiosis-induced TLR signaling pathways in obesity, inflammatory bowel disease (IBD), and colorectal cancer (CRC).
RESULTS: Through the recognition of TLRs, the microbiota facilitates the development of both the innate and adaptive immune systems, while the immune system monitors dynamic changes in the commensal bacteria to maintain the balance of the host-microorganism symbiosis. Dysbiosis of the gut microbiota can induce a cascade of inflammatory and metabolic responses mediated by TLR signaling pathways, potentially resulting in various metabolic and inflammatory diseases.
CONCLUSIONS: Understanding the crosstalk between TLRs and the gut microbiota contributes to potential therapeutic applications in related diseases, offering new avenues for treatment strategies in conditions like obesity, IBD, and CRC.
目的:这篇综述旨在总结肠道菌群与TLR信号通路之间的相互作用,并列举菌群失调诱导的TLR信号通路在肥胖中的作用。炎症性肠病(IBD),结直肠癌(CRC)。
结果:通过识别TLRs,微生物群促进先天和适应性免疫系统的发育,而免疫系统监测共生细菌的动态变化,以维持宿主-微生物共生的平衡。肠道微生物群的菌群失调可以诱导一系列由TLR信号通路介导的炎症和代谢反应,可能导致各种代谢和炎性疾病。
结论:了解TLRs与肠道菌群之间的串扰有助于相关疾病的潜在治疗应用,为肥胖等疾病的治疗策略提供了新的途径,IBD,和CRC。