Abstract：
BACKGROUND: Primary salivary gland carcinomas (SGC) are rare neoplasms that present therapeutic challenges especially in recurrent tumors. The aim of this study was to investigate the incidence and distribution of tumor recurrence, associated risk factors, and survival.
METHODS: This analysis includes data from 318 patients treated for SGC between 1992 and 2020. Survival analysis was performed using the Kaplan-Meier method. Univariate and multivariate analyses were used to identify risk factors associated with recurrence.
RESULTS: 21.7% of the patients developed recurrent disease after a mean of 38.2 months. In multivariate analysis, positive-resection margins, vascular invasion, and tumor localization in the submandibular gland and small salivary glands were independent factors for recurrence. The 5-year overall survival was 67%, the 5-year disease-free survival was 54%.
CONCLUSIONS: Tumor recurrence in SGC occurred in one out of five patients. In highly aggressive entities and patients with risk factors, treatment intensification should be considered.
METHODS: This analysis includes data from 318 patients treated for SGC between 1992 and 2020. Survival analysis was performed using the Kaplan-Meier method. Univariate and multivariate analyses were used to identify risk factors associated with recurrence.
RESULTS: 21.7% of the patients developed recurrent disease after a mean of 38.2 months. In multivariate analysis, positive-resection margins, vascular invasion, and tumor localization in the submandibular gland and small salivary glands were independent factors for recurrence. The 5-year overall survival was 67%, the 5-year disease-free survival was 54%.
CONCLUSIONS: Tumor recurrence in SGC occurred in one out of five patients. In highly aggressive entities and patients with risk factors, treatment intensification should be considered.
摘要：
背景：原发性唾液腺癌（SGC）是罕见的肿瘤，尤其是在复发性肿瘤中，存在治疗挑战。这项研究的目的是调查肿瘤复发的发生率和分布，相关危险因素，和生存。
方法：该分析包括来自1992年至2020年间接受SGC治疗的318名患者的数据。使用Kaplan-Meier方法进行生存分析。使用单变量和多变量分析来确定与复发相关的危险因素。
结果：21.7%的患者在平均38.2个月后出现疾病复发。在多变量分析中，切缘阳性,血管浸润,下颌下腺和小唾液腺的肿瘤定位是复发的独立因素。5年总生存率为67%。5年无病生存率为54%.
结论：5例患者中有1例发生SGC肿瘤复发。在高度攻击性的实体和有危险因素的患者中，应考虑加强治疗。
方法：该分析包括来自1992年至2020年间接受SGC治疗的318名患者的数据。使用Kaplan-Meier方法进行生存分析。使用单变量和多变量分析来确定与复发相关的危险因素。
结果：21.7%的患者在平均38.2个月后出现疾病复发。在多变量分析中，切缘阳性,血管浸润,下颌下腺和小唾液腺的肿瘤定位是复发的独立因素。5年总生存率为67%。5年无病生存率为54%.
结论：5例患者中有1例发生SGC肿瘤复发。在高度攻击性的实体和有危险因素的患者中，应考虑加强治疗。
