Abstract：
On March 31, 2022, severe acute hepatitis of unknown origin was first reported from the Royal Glasgow Children\'s Hospital in Scotland. According to the criteria by WHO-ECDC, a probable case of unknown acute hepatitis in children is defined as a subject under 16 years of age, who tested negative for viral hepatitis and transaminases >500 U/L, starting from the 1st of October 2021. WHO invites Member States to participate in the global effort to collect anonymized clinical data on probable cases of severe acute hepatitis of unknown aetiology. As of May 26, 2021, 650 cases were already registered on the platform worldwide, of whom at least 38 cases have required liver transplants. Several hypotheses such as previous SARS-CoV-2 infection or coinfection or infection with another virus were examined and a strong association was found between adenovirus (41F) and acute hepatitis of unknown aetiology cases. This review article summarizes the global epidemiological evidences on acute hepatitis of unknown origin in children, analysing their incidence and characteristics.
摘要：
2022年3月31日，苏格兰皇家格拉斯哥儿童医院首次报告了来历不明的严重急性肝炎。根据WHO-ECDC的标准，儿童不明急性肝炎的可能病例定义为16岁以下的受试者，病毒性肝炎和转氨酶>500U/L检测呈阴性，从2021年10月1日开始。世卫组织请会员国参与全球努力，收集病因不明的严重急性肝炎可能病例的匿名临床数据。截至2021年5月26日，全球已有650例病例在该平台上注册，其中至少有38例需要肝移植。检查了几种假设，例如以前的SARS-CoV-2感染或合并感染或与另一种病毒的感染，发现腺病毒（41F）与病因不明的急性肝炎之间存在很强的关联。这篇综述文章总结了全球儿童不明原因急性肝炎的流行病学证据。分析其发病率和特点。
