Abstract：
Transposable elements (TEs) have emerged as important factors in establishing the cell type-specific gene regulatory networks and evolutionary novelty of embryonic and placental development. Recently, studies on the role of TEs and their dysregulation in cancers have shed light on the transcriptional, transpositional, and regulatory activity of TEs, revealing that the activation of developmental transcriptional programs by TEs may have a role in the dedifferentiation of cancer cells to the progenitor-like cell states. This essay reviews the recent evidence of the cis-regulatory TEs (henceforth crTE) in normal development and malignancy as well as the key transcription factors and regulatory pathways that are implicated in both cell states, and presents existing gaps remaining to be studied, limitations of current technologies, and therapeutic possibilities.
摘要：
转座因子（TE）已成为建立细胞类型特异性基因调控网络以及胚胎和胎盘发育进化新颖性的重要因素。最近,关于TEs的作用及其在癌症中失调的研究揭示了转录，换位,和TE的监管活动，揭示TEs激活发育转录程序可能在癌细胞去分化为祖细胞样细胞状态中起作用。本文回顾了顺式调节TEs（以下简称crTE）在正常发育和恶性肿瘤中的最新证据，以及与两种细胞状态有关的关键转录因子和调节途径。并提出了尚待研究的现有差距，当前技术的局限性，和治疗的可能性。
