Abstract：
BACKGROUND: Older adults with multimorbidity are at high risk of cognitive impairment development. There is a lack of research on the associations between different multimorbidity measures and cognitive function among older Chinese adults living in the community.
METHODS: We used the Chinese Longitudinal Healthy Longevity Survey from 2002 to 2018 and included data on dementia-free participants aged ≥65 years. Multimorbidity measures included condition counts, multimorbidity patterns, and trajectories. The association of multimorbidity measures with cognitive function was examined by generalized estimating equation and linear and logistic regression models.
RESULTS: Among 14,093 participants at baseline, 43.2% had multimorbidity. Multimorbidity patterns were grouped into cancer-inflammatory, cardiometabolic, and sensory patterns. Multimorbidity trajectories were classified as \"onset-condition,\" \"newly developing,\" and \"severe condition.\" The Mini-Mental State Examination scores were significantly lower for participants with more chronic conditions, with cancer-inflammatory/cardiometabolic/sensory patterns, and with developing multimorbidity trajectories.
CONCLUSIONS: Condition counts, sensory pattern, cardiometabolic pattern, cancer-inflammatory pattern, and multimorbidity developmental trajectories were prospectively associated with cognitive function.
CONCLUSIONS: Elderly individuals with a higher number of chronic conditions were associated with lower MMSE scores in the Chinese Longitudinal Healthy Longevity Survey data. MMSE scores were significantly lower for participants with specific multimorbidity patterns. Individuals with developing trajectories of multimorbidity were associated with lower MMSE scores and a higher risk of mild cognitive impairment.
METHODS: We used the Chinese Longitudinal Healthy Longevity Survey from 2002 to 2018 and included data on dementia-free participants aged ≥65 years. Multimorbidity measures included condition counts, multimorbidity patterns, and trajectories. The association of multimorbidity measures with cognitive function was examined by generalized estimating equation and linear and logistic regression models.
RESULTS: Among 14,093 participants at baseline, 43.2% had multimorbidity. Multimorbidity patterns were grouped into cancer-inflammatory, cardiometabolic, and sensory patterns. Multimorbidity trajectories were classified as \"onset-condition,\" \"newly developing,\" and \"severe condition.\" The Mini-Mental State Examination scores were significantly lower for participants with more chronic conditions, with cancer-inflammatory/cardiometabolic/sensory patterns, and with developing multimorbidity trajectories.
CONCLUSIONS: Condition counts, sensory pattern, cardiometabolic pattern, cancer-inflammatory pattern, and multimorbidity developmental trajectories were prospectively associated with cognitive function.
CONCLUSIONS: Elderly individuals with a higher number of chronic conditions were associated with lower MMSE scores in the Chinese Longitudinal Healthy Longevity Survey data. MMSE scores were significantly lower for participants with specific multimorbidity patterns. Individuals with developing trajectories of multimorbidity were associated with lower MMSE scores and a higher risk of mild cognitive impairment.
摘要：
背景：患有多重性疾病的老年人有发生认知障碍的高风险。缺乏对居住在社区中的中国老年人的不同多发病率指标与认知功能之间的关联的研究。
方法：我们使用了2002年至2018年的中国纵向健康长寿调查，并纳入了年龄≥65岁的无痴呆参与者的数据。多浊度测量包括条件计数，多浊度模式，和轨迹。通过广义估计方程以及线性和逻辑回归模型检查了多发病率测量与认知功能的关联。
结果：在基线时的14093名参与者中，43.2%有多发病率。多发病率模式分为癌症-炎症，心脏代谢，和感官模式。多症轨迹被归类为“发病条件”，\"\"新开发的，\"和\"严重的情况。“对于慢性疾病较多的参与者，迷你精神状态检查分数明显较低，癌症炎症/心脏代谢/感觉模式，以及不断发展的多浊度轨迹。
结论：条件计数，感官模式，心脏代谢模式，癌症炎症模式，多发病发育轨迹与认知功能前瞻性相关。
结论：在中国纵向健康长寿调查数据中，慢性疾病数量较多的老年人与较低的MMSE评分相关。对于具有特定多患病模式的参与者，MMSE评分明显较低。具有多发病发展轨迹的个体与较低的MMSE评分和较高的轻度认知障碍风险相关。
方法：我们使用了2002年至2018年的中国纵向健康长寿调查，并纳入了年龄≥65岁的无痴呆参与者的数据。多浊度测量包括条件计数，多浊度模式，和轨迹。通过广义估计方程以及线性和逻辑回归模型检查了多发病率测量与认知功能的关联。
结果：在基线时的14093名参与者中，43.2%有多发病率。多发病率模式分为癌症-炎症，心脏代谢，和感官模式。多症轨迹被归类为“发病条件”，\"\"新开发的，\"和\"严重的情况。“对于慢性疾病较多的参与者，迷你精神状态检查分数明显较低，癌症炎症/心脏代谢/感觉模式，以及不断发展的多浊度轨迹。
结论：条件计数，感官模式，心脏代谢模式，癌症炎症模式，多发病发育轨迹与认知功能前瞻性相关。
结论：在中国纵向健康长寿调查数据中，慢性疾病数量较多的老年人与较低的MMSE评分相关。对于具有特定多患病模式的参与者，MMSE评分明显较低。具有多发病发展轨迹的个体与较低的MMSE评分和较高的轻度认知障碍风险相关。
