关键词: Aquaporin-4 Neuromyelitis Rheumatoid arthritis

Mesh : Humans Arthritis, Rheumatoid / complications drug therapy Neuromyelitis Optica / drug therapy complications Female Magnetic Resonance Imaging Glucocorticoids / therapeutic use Aquaporin 4 / immunology Middle Aged Immunosuppressive Agents / therapeutic use Autoantibodies / blood

来  源:   DOI:10.34172/aim.28804   PDF(Pubmed)

Abstract:
A patient with longstanding rheumatoid arthritis (RA) complained of spinal cord symptoms after RA relapse. Contrast MRI demonstrated neuromyelitis in the upper thoracic spinal cord, and anti-aquaporin-4 (anti-AQP4) antibody was positive in the serum and cerebrospinal fluid (CSF). Neuromyelitis optica spectrum disorder (NMOSD) was diagnosed after excluding central nervous system (CNS) infection and tumor, and spinal cord symptoms were relieved after high dose of glucocorticoid and immunosuppressant were initiated for treatment.
摘要:
长期患有类风湿性关节炎(RA)的患者在RA复发后抱怨脊髓症状。对比MRI显示上胸椎脊髓神经脊髓炎,血清和脑脊液(CSF)中抗水通道蛋白4(抗AQP4)抗体呈阳性。视神经脊髓炎谱系障碍(NMOSD)在排除中枢神经系统(CNS)感染和肿瘤后被诊断,大剂量糖皮质激素和免疫抑制剂治疗后脊髓症状缓解。
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