PDF(Pubmed)
Abstract：
Vagus nerve stimulation (VNS) is acknowledged as a highly effective therapy for various neurological conditions, including refractory epilepsy, depression, Alzheimer\'s disease (AD), migraine, and stroke. Presently, there is an increasing focus on understanding the impact of VNS on cognitive aspects. Numerous studies suggest that VNS suppresses the body\'s inflammatory response, leading to enhanced cognitive function in patients. Vascular cognitive impairment (VCI) is a severe cognitive dysfunction syndrome resulting from prolonged chronic cerebral hypoperfusion (CCH), where the primary pathogenesis is CCH-induced neuroinflammation. In this paper, we present a comprehensive overview of the research advancements in using VNS for treating VCI and discuss that VNS improves cognitive function in VCI patients by suppressing neuroinflammation, offering insights into a potential novel approach for addressing this condition.
摘要：
迷走神经刺激（VNS）是公认的各种神经系统疾病的高效疗法，包括难治性癫痫,抑郁症,阿尔茨海默病（AD），偏头痛,和中风。目前,人们越来越关注了解VNS对认知方面的影响。大量研究表明，VNS抑制身体的炎症反应，导致患者认知功能增强。血管性认知障碍(VCI)是由长期慢性脑低灌注(CCH)引起的严重认知功能障碍综合征,其中主要发病机制是CCH诱导的神经炎症。在本文中,我们全面概述了使用VNS治疗VCI的研究进展，并讨论了VNS通过抑制神经炎症改善VCI患者的认知功能，提供解决这种情况的潜在新方法的见解。
