PDF(Pubmed)
Abstract：
UNASSIGNED: The dietary fat hypothesis links increases in allergic diseases to reduced consumption of n-3 polyunsaturated fatty acids from fish, for example, eicosapentaenoic acid, and increased intake of n-6 polyunsaturated fatty acids from vegetable oils, for example, arachidonic acid.
UNASSIGNED: Building upon the \"fat hypothesis,\" we sought to investigate the association between 24 types of serum fatty acid levels in infants and the risk of subsequent food-induced anaphylaxis (FIA) by age 2 years as the primary outcome.
UNASSIGNED: This study was conducted as a prespecified supplemental analysis within the ABC randomized clinical trial. We measured levels of 24 fatty acids in residual serum samples collected from 268 infants at age 5 to 6 months using gas chromatography-mass spectrometry.
UNASSIGNED: Among the 258 infants, 58 exhibited immediate-type food allergies, whereas 200 showed no food allergy. Of the 58 infants, 12 were diagnosed with FIA, whereas the remaining 46 had nonanaphylactic food allergy. Unexpectedly, among the 24 fatty acids, only adrenic acid, also known as docosatetraenoic acid, which is one of the n-6 polyunsaturated fatty acids, showed significantly lower levels in infants with FIA (median [interquartile range] (wt.%), 0.16 [0.14-0.17]), compared with those with no food allergy (0.19 [0.17-0.21]) (P = .0007). In contrast, adrenic acid levels in infants with nonanaphylactic food allergy were 0.19 [0.16-0.21] (wt.%), which did not differ significantly from those in infants with no food allergy (P = .69).
UNASSIGNED: This study generated a hypothesis suggesting that infants with low serum adrenic acid levels might be at greater risk of subsequent FIA. This unexpected result warrants further investigation.
UNASSIGNED: Building upon the \"fat hypothesis,\" we sought to investigate the association between 24 types of serum fatty acid levels in infants and the risk of subsequent food-induced anaphylaxis (FIA) by age 2 years as the primary outcome.
UNASSIGNED: This study was conducted as a prespecified supplemental analysis within the ABC randomized clinical trial. We measured levels of 24 fatty acids in residual serum samples collected from 268 infants at age 5 to 6 months using gas chromatography-mass spectrometry.
UNASSIGNED: Among the 258 infants, 58 exhibited immediate-type food allergies, whereas 200 showed no food allergy. Of the 58 infants, 12 were diagnosed with FIA, whereas the remaining 46 had nonanaphylactic food allergy. Unexpectedly, among the 24 fatty acids, only adrenic acid, also known as docosatetraenoic acid, which is one of the n-6 polyunsaturated fatty acids, showed significantly lower levels in infants with FIA (median [interquartile range] (wt.%), 0.16 [0.14-0.17]), compared with those with no food allergy (0.19 [0.17-0.21]) (P = .0007). In contrast, adrenic acid levels in infants with nonanaphylactic food allergy were 0.19 [0.16-0.21] (wt.%), which did not differ significantly from those in infants with no food allergy (P = .69).
UNASSIGNED: This study generated a hypothesis suggesting that infants with low serum adrenic acid levels might be at greater risk of subsequent FIA. This unexpected result warrants further investigation.
摘要：
■饮食脂肪假说增加了过敏性疾病与减少鱼类中n-3多不饱和脂肪酸的消耗，例如,二十碳五烯酸,从植物油中摄入n-6多不饱和脂肪酸，例如,花生四烯酸。
■建立在“脂肪假说”的基础上，“我们试图调查婴儿中24种类型的血清脂肪酸水平与作为主要结局的2岁时随后的食物诱导过敏反应（FIA）风险之间的关系。
本研究作为ABC随机临床试验中的预设补充分析进行。我们使用气相色谱-质谱法测量了从268名5至6个月大的婴儿收集的残留血清样品中24种脂肪酸的水平。
■在258名婴儿中，58人表现出即时型食物过敏，而200则没有食物过敏。在58个婴儿中，12人被诊断为国际汽联，而其余46例有非过敏性食物过敏.出乎意料的是,在24种脂肪酸中，只有肾上腺酸，也被称为二十二碳四烯酸，它是n-6多不饱和脂肪酸之一，FIA婴儿的水平显着降低（中位数[四分位数间距]（wt。%),0.16[0.14-0.17])，与没有食物过敏的人相比（0.19[0.17-0.21]）（P=.0007）。相比之下,非过敏性食物过敏婴儿的肾上腺酸水平为0.19[0.16-0.21]（wt.%),这与没有食物过敏的婴儿没有显着差异（P=0.69）。
■这项研究产生了一个假设，表明血清肾上腺素水平低的婴儿可能在随后的FIA风险更大。这一意外结果值得进一步调查。
■建立在“脂肪假说”的基础上，“我们试图调查婴儿中24种类型的血清脂肪酸水平与作为主要结局的2岁时随后的食物诱导过敏反应（FIA）风险之间的关系。
本研究作为ABC随机临床试验中的预设补充分析进行。我们使用气相色谱-质谱法测量了从268名5至6个月大的婴儿收集的残留血清样品中24种脂肪酸的水平。
■在258名婴儿中，58人表现出即时型食物过敏，而200则没有食物过敏。在58个婴儿中，12人被诊断为国际汽联，而其余46例有非过敏性食物过敏.出乎意料的是,在24种脂肪酸中，只有肾上腺酸，也被称为二十二碳四烯酸，它是n-6多不饱和脂肪酸之一，FIA婴儿的水平显着降低（中位数[四分位数间距]（wt。%),0.16[0.14-0.17])，与没有食物过敏的人相比（0.19[0.17-0.21]）（P=.0007）。相比之下,非过敏性食物过敏婴儿的肾上腺酸水平为0.19[0.16-0.21]（wt.%),这与没有食物过敏的婴儿没有显着差异（P=0.69）。
■这项研究产生了一个假设，表明血清肾上腺素水平低的婴儿可能在随后的FIA风险更大。这一意外结果值得进一步调查。
