PDF(Pubmed)
Abstract：
UNASSIGNED: Severe asthma pathology encompasses a wide range of pulmonary and extrapulmonary treatable traits with a high prevalence of comorbidities. Although asthma-specific health-related quality-of-life measures are most sensitive to changes in asthma control, generic measures, such as EQ-5D-5L (EuroQol 5-Dimension 5-Level questionnaire), are potentially better for capturing the impact of comorbidities.
UNASSIGNED: We sought to examine the impact of pulmonary and extrapulmonary treatable traits on quality of life at initial severe asthma assessment, and to compare the characteristics of those patients whose quality of life does and does not improve during follow-up at severe asthma centers.
UNASSIGNED: Patients\' characteristics at baseline assessment within the UK Severe Asthma Registry were compared by EQ-5D-5L utility index quartile. Patients with follow-up review data were stratified by change in EQ-5D-5L utility index from baseline to follow-up, and characteristics similarly examined.
UNASSIGNED: Patients in the quartiles with worst dysutility at baseline were observed to exhibit more treatable traits and in particular extrapulmonary traits associated with cumulative systemic corticosteroids, including obesity, anxiety/depression, and osteoporosis. In those patients whose quality of life improved over follow-up, a reduction in exacerbations, uncontrolled symptoms, and requirement for maintenance oral corticosteroids were observed.
UNASSIGNED: Both pulmonary and extrapulmonary treatable traits are important determinants of quality of life in severe asthma. Comorbidities associated with cumulative systemic corticosteroid exposure are particularly associated with worse quality of life, emphasizing the importance of early identification and management of severe asthma before comorbidities develop.
UNASSIGNED: We sought to examine the impact of pulmonary and extrapulmonary treatable traits on quality of life at initial severe asthma assessment, and to compare the characteristics of those patients whose quality of life does and does not improve during follow-up at severe asthma centers.
UNASSIGNED: Patients\' characteristics at baseline assessment within the UK Severe Asthma Registry were compared by EQ-5D-5L utility index quartile. Patients with follow-up review data were stratified by change in EQ-5D-5L utility index from baseline to follow-up, and characteristics similarly examined.
UNASSIGNED: Patients in the quartiles with worst dysutility at baseline were observed to exhibit more treatable traits and in particular extrapulmonary traits associated with cumulative systemic corticosteroids, including obesity, anxiety/depression, and osteoporosis. In those patients whose quality of life improved over follow-up, a reduction in exacerbations, uncontrolled symptoms, and requirement for maintenance oral corticosteroids were observed.
UNASSIGNED: Both pulmonary and extrapulmonary treatable traits are important determinants of quality of life in severe asthma. Comorbidities associated with cumulative systemic corticosteroid exposure are particularly associated with worse quality of life, emphasizing the importance of early identification and management of severe asthma before comorbidities develop.
摘要：
严重的哮喘病理包括广泛的肺部和肺外可治疗的特征，并伴有高患病率的合并症。尽管与哮喘相关的健康生活质量指标对哮喘控制的变化最敏感，通用措施，如EQ-5D-5L(EuroQol5维5级问卷)，对于捕捉合并症的影响可能更好。
■我们试图在初始严重哮喘评估时检查肺部和肺外可治疗特征对生活质量的影响，并比较那些在重症哮喘中心随访期间生活质量改善和未改善的患者的特征。
■通过EQ-5D-5L效用指数四分位数比较了英国重度哮喘注册中心基线评估时的患者特征。对有随访回顾数据的患者进行从基线到随访的EQ-5D-5L效用指数的变化分层，和类似检查的特征。
■观察到基线时运动不良的四分位数患者表现出更多可治疗的特征，特别是与累积的全身性皮质类固醇相关的肺外特征。包括肥胖,焦虑/抑郁,和骨质疏松症。在那些生活质量改善的患者中，恶化的减少，不受控制的症状，并观察到维持口服糖皮质激素的需求。
■肺部和肺外可治疗的特征都是严重哮喘患者生活质量的重要决定因素。与累积的全身性皮质类固醇暴露相关的合并症尤其与较差的生活质量相关。强调在合并症发展之前早期识别和管理严重哮喘的重要性。
■我们试图在初始严重哮喘评估时检查肺部和肺外可治疗特征对生活质量的影响，并比较那些在重症哮喘中心随访期间生活质量改善和未改善的患者的特征。
■通过EQ-5D-5L效用指数四分位数比较了英国重度哮喘注册中心基线评估时的患者特征。对有随访回顾数据的患者进行从基线到随访的EQ-5D-5L效用指数的变化分层，和类似检查的特征。
■观察到基线时运动不良的四分位数患者表现出更多可治疗的特征，特别是与累积的全身性皮质类固醇相关的肺外特征。包括肥胖,焦虑/抑郁,和骨质疏松症。在那些生活质量改善的患者中，恶化的减少，不受控制的症状，并观察到维持口服糖皮质激素的需求。
■肺部和肺外可治疗的特征都是严重哮喘患者生活质量的重要决定因素。与累积的全身性皮质类固醇暴露相关的合并症尤其与较差的生活质量相关。强调在合并症发展之前早期识别和管理严重哮喘的重要性。
