PDF(Pubmed)
Abstract：
UNASSIGNED: Due to its obscure etiology and diverse clinical manifestations, the treatment of subdural effusion, presents challenges, and the condition\'s progression to chronic subdural hematoma(cSDH) often necessitates surgical intervention.This study reports on two pediatric patients who developed progressive subdural effusion following minor head injuries. Both cases were notable for the detection of low levels of human herpesvirus in the cerebrospinal fluid, despite other tests returning negative. Immunotherapy led to a dramatic absorption of their subdural effusions, resulting in very positive clinical outcome.
UNASSIGNED: Case 1: This involved a 4-year and 1-month-old boy who was diagnosed with acute cerebellitis due to an unstable gait following a fall. After being discharged, he sustained another minor head injury. A follow-up Magnetic Resonance Imaging (MRI) revealed an increasing and shifting subdural effusion, which was rapidly absorbed following treatment with high doses of methylprednisolone.Case 2: A 6-year and 3-month-old boy presented with headaches following a minor fall. He improved after treatment with intravenous immunoglobulin and low-dose methylprednisolone. The subdural effusion was completely absorbed, and his health remained stable four months after discharge.
UNASSIGNED: Our findings suggest that immune inflammation may play a critical role in the development of subdural effusion. The successful treatment outcomes emphasize the potential of immunotherapy as a non-invasive option for managing subdural effusion, particularly in children with unexplained conditions following minor trauma.
UNASSIGNED: Case 1: This involved a 4-year and 1-month-old boy who was diagnosed with acute cerebellitis due to an unstable gait following a fall. After being discharged, he sustained another minor head injury. A follow-up Magnetic Resonance Imaging (MRI) revealed an increasing and shifting subdural effusion, which was rapidly absorbed following treatment with high doses of methylprednisolone.Case 2: A 6-year and 3-month-old boy presented with headaches following a minor fall. He improved after treatment with intravenous immunoglobulin and low-dose methylprednisolone. The subdural effusion was completely absorbed, and his health remained stable four months after discharge.
UNASSIGNED: Our findings suggest that immune inflammation may play a critical role in the development of subdural effusion. The successful treatment outcomes emphasize the potential of immunotherapy as a non-invasive option for managing subdural effusion, particularly in children with unexplained conditions following minor trauma.
摘要：
■由于其病因不明，临床表现多样，硬膜下积液的治疗，提出挑战，并且病情进展为慢性硬膜下血肿（cSDH）通常需要手术干预。这项研究报告了两名小儿患者，他们在头部轻伤后出现进行性硬膜下积液。两例均以脑脊液中低水平的人疱疹病毒为特征，尽管其他测试返回阴性。免疫治疗导致硬膜下积液的戏剧性吸收，导致非常积极的临床结果。
病例1：1名4岁零1个月大的男孩因跌倒后步态不稳定而被诊断为急性小脑炎。出院后,他头部又受了轻伤。随访磁共振成像（MRI）显示硬膜下积液增加和移位，高剂量甲基强的松龙治疗后迅速吸收。案例2：一个6岁零3个月大的男孩在轻微跌倒后出现头痛。静脉注射免疫球蛋白和低剂量甲基强的松龙治疗后病情好转。硬膜下积液完全吸收,出院四个月后，他的健康状况保持稳定。
■我们的研究结果表明，免疫炎症可能在硬膜下积液的发展中起关键作用。成功的治疗结果强调了免疫治疗作为治疗硬膜下积液的非侵入性选择的潜力。特别是在轻微创伤后无法解释的儿童中。
病例1：1名4岁零1个月大的男孩因跌倒后步态不稳定而被诊断为急性小脑炎。出院后,他头部又受了轻伤。随访磁共振成像（MRI）显示硬膜下积液增加和移位，高剂量甲基强的松龙治疗后迅速吸收。案例2：一个6岁零3个月大的男孩在轻微跌倒后出现头痛。静脉注射免疫球蛋白和低剂量甲基强的松龙治疗后病情好转。硬膜下积液完全吸收,出院四个月后，他的健康状况保持稳定。
■我们的研究结果表明，免疫炎症可能在硬膜下积液的发展中起关键作用。成功的治疗结果强调了免疫治疗作为治疗硬膜下积液的非侵入性选择的潜力。特别是在轻微创伤后无法解释的儿童中。
