PDF(Pubmed)
Abstract：
UNASSIGNED: This research sought to explore the association between the triglyceride-glucose (TyG) index and the risk of sarcopenia in patients with chronic inflammatory airway disease (CIAD).
UNASSIGNED: Data were obtained from the National Health and Nutrition Examination Survey 2011-2018. Grouping was performed using TyG index tertiles and multiple logistic regression was employed to assess the correlation between TyG levels and the risk of sarcopenia. The Receiver Operating Characteristic (ROC) curve analysis was conducted to determine the prognostic value of the TyG index for sarcopenia. Linear regression analysis was utilized to elucidate the direct relationship between TyG index and sarcopenia. Additionally, the curve between the TyG and sarcopenia indices was examined using a generalized additive model.
UNASSIGNED: The study included 981 individuals diagnosed with CIAD. After adjusting for potential confounders, a significant positive correlation was observed between TyG and sarcopenia (OR = 1.70, 95 % CI: 1.20-2.39, P = 0.002). Trend analysis using the chi-square test revealed an increase in sarcopenia prevalence concomitant with higher TyG levels (P < 0.05). Furthermore, linear regression analysis revealed a notable inverse linear association between the TyG and sarcopenia indices (β = -0.03; 95 % CI: -0.07-0.01; P = 0.020). The ROC curves corroborated the robust predictive capacity of TyG for sarcopenia among patients with CIAD, with an AUC of 0.685 (95 % CI: 0.636-0.735, P < 0.001).
UNASSIGNED: Our research indicates a positive association between TyG and sarcopenia in CIAD patients. The TyG index may serve as a reliable marker for predicting sarcopenia risk in CIAD patients.
UNASSIGNED: Data were obtained from the National Health and Nutrition Examination Survey 2011-2018. Grouping was performed using TyG index tertiles and multiple logistic regression was employed to assess the correlation between TyG levels and the risk of sarcopenia. The Receiver Operating Characteristic (ROC) curve analysis was conducted to determine the prognostic value of the TyG index for sarcopenia. Linear regression analysis was utilized to elucidate the direct relationship between TyG index and sarcopenia. Additionally, the curve between the TyG and sarcopenia indices was examined using a generalized additive model.
UNASSIGNED: The study included 981 individuals diagnosed with CIAD. After adjusting for potential confounders, a significant positive correlation was observed between TyG and sarcopenia (OR = 1.70, 95 % CI: 1.20-2.39, P = 0.002). Trend analysis using the chi-square test revealed an increase in sarcopenia prevalence concomitant with higher TyG levels (P < 0.05). Furthermore, linear regression analysis revealed a notable inverse linear association between the TyG and sarcopenia indices (β = -0.03; 95 % CI: -0.07-0.01; P = 0.020). The ROC curves corroborated the robust predictive capacity of TyG for sarcopenia among patients with CIAD, with an AUC of 0.685 (95 % CI: 0.636-0.735, P < 0.001).
UNASSIGNED: Our research indicates a positive association between TyG and sarcopenia in CIAD patients. The TyG index may serve as a reliable marker for predicting sarcopenia risk in CIAD patients.
摘要：
■这项研究试图探索甘油三酸酯-葡萄糖（TyG）指数与慢性炎症性气道疾病（CIAD）患者肌肉减少症风险之间的关系。
■数据来自2011-2018年全国健康和营养检查调查。使用TyG指数进行分组，并采用多元逻辑回归评估TyG水平与肌肉减少症风险之间的相关性。进行受试者工作特征（ROC）曲线分析以确定TyG指数对肌肉减少症的预后价值。线性回归分析用于阐明TyG指数与肌肉减少症之间的直接关系。此外,TyG指数和肌少症指数之间的曲线采用广义加性模型进行检验.
■该研究包括981名诊断为CIAD的个体。在调整了潜在的混杂因素后，TyG与肌肉减少症呈显著正相关(OR=1.70,95%CI:1.20~2.39,P=0.002)。使用卡方检验的趋势分析显示，随着TyG水平的升高，肌少症患病率增加（P<0.05）。此外，线性回归分析显示，TyG和肌少症指数之间存在显著的负线性相关(β=-0.03;95%CI:-0.07-0.01;P=0.020)。ROC曲线证实了TyG对CIAD患者肌肉减少症的稳健预测能力，AUC为0.685（95%CI：0.636-0.735，P<0.001）。
■我们的研究表明，在CI型AD患者中，TyG与肌肉减少症之间存在正相关。TyG指数可作为预测CIAD患者少肌症风险的可靠指标。
■数据来自2011-2018年全国健康和营养检查调查。使用TyG指数进行分组，并采用多元逻辑回归评估TyG水平与肌肉减少症风险之间的相关性。进行受试者工作特征（ROC）曲线分析以确定TyG指数对肌肉减少症的预后价值。线性回归分析用于阐明TyG指数与肌肉减少症之间的直接关系。此外,TyG指数和肌少症指数之间的曲线采用广义加性模型进行检验.
■该研究包括981名诊断为CIAD的个体。在调整了潜在的混杂因素后，TyG与肌肉减少症呈显著正相关(OR=1.70,95%CI:1.20~2.39,P=0.002)。使用卡方检验的趋势分析显示，随着TyG水平的升高，肌少症患病率增加（P<0.05）。此外，线性回归分析显示，TyG和肌少症指数之间存在显著的负线性相关(β=-0.03;95%CI:-0.07-0.01;P=0.020)。ROC曲线证实了TyG对CIAD患者肌肉减少症的稳健预测能力，AUC为0.685（95%CI：0.636-0.735，P<0.001）。
■我们的研究表明，在CI型AD患者中，TyG与肌肉减少症之间存在正相关。TyG指数可作为预测CIAD患者少肌症风险的可靠指标。
