PDF(Pubmed)
Abstract：
UNASSIGNED: Limited data exists on the impact of inflammatory cells and clinical characteristics on lung function in individuals with asthma.
UNASSIGNED: The objective is to examine the correlation between increased inflammatory cells, asthma symptoms, and lung function in patients with asthma in a clinical setting.
UNASSIGNED: A retrospective cohort study was conducted on 234 individuals suspected of having asthma in Xian, China between January 2008 and December 2021. Of those, 143 patients with complete clinical feature and lung function data were enrolled to examine the relationship between increased inflammatory cells, asthma symptoms, and lung function. Basic characteristics, blood eosinophil count, blood neutrophil count, blood platelet count, blood C-reactive protein (CRP), and comprehensive lung function analysis were evaluated at each inpatient for the 143 adult asthmatics. The association between inflammatory cells and clinical parameters with pulmonary function was compared.
UNASSIGNED: The results of the study showed that individuals in the alcohol intake group had elevated blood eosinophil count compared to those in the non-alcohol intake group (P = 0.024). Long-acting inhaled beta 2 agonists and antibiotic therapy were associated with lower blood eosinophil count (P = 0.021 and P = 0.049, respectively) compared to other therapy. There was a independent association between blood eosinophil counts and FEV1 pre- and post-therapy in asthma but there was a markedly correlation between blood eosinophil counts and FEV1/FVC pre-and post-therapy in Asthma (P = 0.007). Blood neutrophil counts were inversely correlated with FEV1/FVC after treatment (P = 0.032). Night onset in asthma was positively correlated with blood neutrophil counts, while fever was negatively correlated with blood CRP (P = 0.028). Platelet counts >300 × 109/L after treatment were significantly associated with a decline in FEV (<0.001) in patients with asthma. Elevated blood eosinophil count was independently associated with clinical features in asthma.
UNASSIGNED: Based on the study\'s findings, there is a significant decline in FEV1/FVC among individuals with elevated blood eosinophil count, both pre- and post-bronchodilator while there was a independent relationship between blood eosinophil counts and FEV1 pre-and post-therapy in asthma. This suggests that increased levels of eosinophils may independently associated contribute to reduced lung function in asthma patients.
UNASSIGNED: The objective is to examine the correlation between increased inflammatory cells, asthma symptoms, and lung function in patients with asthma in a clinical setting.
UNASSIGNED: A retrospective cohort study was conducted on 234 individuals suspected of having asthma in Xian, China between January 2008 and December 2021. Of those, 143 patients with complete clinical feature and lung function data were enrolled to examine the relationship between increased inflammatory cells, asthma symptoms, and lung function. Basic characteristics, blood eosinophil count, blood neutrophil count, blood platelet count, blood C-reactive protein (CRP), and comprehensive lung function analysis were evaluated at each inpatient for the 143 adult asthmatics. The association between inflammatory cells and clinical parameters with pulmonary function was compared.
UNASSIGNED: The results of the study showed that individuals in the alcohol intake group had elevated blood eosinophil count compared to those in the non-alcohol intake group (P = 0.024). Long-acting inhaled beta 2 agonists and antibiotic therapy were associated with lower blood eosinophil count (P = 0.021 and P = 0.049, respectively) compared to other therapy. There was a independent association between blood eosinophil counts and FEV1 pre- and post-therapy in asthma but there was a markedly correlation between blood eosinophil counts and FEV1/FVC pre-and post-therapy in Asthma (P = 0.007). Blood neutrophil counts were inversely correlated with FEV1/FVC after treatment (P = 0.032). Night onset in asthma was positively correlated with blood neutrophil counts, while fever was negatively correlated with blood CRP (P = 0.028). Platelet counts >300 × 109/L after treatment were significantly associated with a decline in FEV (<0.001) in patients with asthma. Elevated blood eosinophil count was independently associated with clinical features in asthma.
UNASSIGNED: Based on the study\'s findings, there is a significant decline in FEV1/FVC among individuals with elevated blood eosinophil count, both pre- and post-bronchodilator while there was a independent relationship between blood eosinophil counts and FEV1 pre-and post-therapy in asthma. This suggests that increased levels of eosinophils may independently associated contribute to reduced lung function in asthma patients.
摘要：
■关于炎症细胞和临床特征对哮喘患者肺功能的影响的数据有限。
■目的是检查炎症细胞增加之间的相关性，哮喘症状,在临床上哮喘患者的肺功能。
■一项回顾性队列研究在西安对234名疑似哮喘患者进行，2008年1月至2021年12月的中国。其中,143名具有完整临床特征和肺功能数据的患者被纳入，以检查炎症细胞增加之间的关系，哮喘症状,和肺功能。基本特征,血嗜酸性粒细胞计数,血液中性粒细胞计数,血小板计数,血C反应蛋白（CRP），对143例成人哮喘患者的每个住院患者进行了综合肺功能分析。比较了炎症细胞和临床参数与肺功能之间的关系。
■研究结果表明，与非饮酒组相比，饮酒组的个体血液嗜酸性粒细胞计数升高（P=0.024）。与其他治疗相比，长效吸入β2激动剂和抗生素治疗与更低的血液嗜酸性粒细胞计数相关（分别为P=0.021和P=0.049）。哮喘患者治疗前后血嗜酸性粒细胞计数与FEV1存在独立相关性，但哮喘患者治疗前后血嗜酸性粒细胞计数与FEV1/FVC存在显著相关性（P=0.007）。治疗后血液中性粒细胞计数与FEV1/FVC呈负相关(P=0.032)。哮喘夜间发作与血中性粒细胞计数呈正相关,发热与血CRP呈负相关(P=0.028)。治疗后血小板计数>300×109/L与哮喘患者FEV下降(<0.001)显著相关。血嗜酸性粒细胞计数升高与哮喘的临床特征独立相关。
■根据研究结果，在血液嗜酸性粒细胞计数升高的个体中，FEV1/FVC显着下降，支气管扩张剂治疗前后均存在独立的相关性,而哮喘患者治疗前后的血嗜酸性粒细胞计数与FEV1之间存在独立的相关性.这表明嗜酸性粒细胞水平的升高可能独立地导致哮喘患者肺功能降低。
■目的是检查炎症细胞增加之间的相关性，哮喘症状,在临床上哮喘患者的肺功能。
■一项回顾性队列研究在西安对234名疑似哮喘患者进行，2008年1月至2021年12月的中国。其中,143名具有完整临床特征和肺功能数据的患者被纳入，以检查炎症细胞增加之间的关系，哮喘症状,和肺功能。基本特征,血嗜酸性粒细胞计数,血液中性粒细胞计数,血小板计数,血C反应蛋白（CRP），对143例成人哮喘患者的每个住院患者进行了综合肺功能分析。比较了炎症细胞和临床参数与肺功能之间的关系。
■研究结果表明，与非饮酒组相比，饮酒组的个体血液嗜酸性粒细胞计数升高（P=0.024）。与其他治疗相比，长效吸入β2激动剂和抗生素治疗与更低的血液嗜酸性粒细胞计数相关（分别为P=0.021和P=0.049）。哮喘患者治疗前后血嗜酸性粒细胞计数与FEV1存在独立相关性，但哮喘患者治疗前后血嗜酸性粒细胞计数与FEV1/FVC存在显著相关性（P=0.007）。治疗后血液中性粒细胞计数与FEV1/FVC呈负相关(P=0.032)。哮喘夜间发作与血中性粒细胞计数呈正相关,发热与血CRP呈负相关(P=0.028)。治疗后血小板计数>300×109/L与哮喘患者FEV下降(<0.001)显著相关。血嗜酸性粒细胞计数升高与哮喘的临床特征独立相关。
■根据研究结果，在血液嗜酸性粒细胞计数升高的个体中，FEV1/FVC显着下降，支气管扩张剂治疗前后均存在独立的相关性,而哮喘患者治疗前后的血嗜酸性粒细胞计数与FEV1之间存在独立的相关性.这表明嗜酸性粒细胞水平的升高可能独立地导致哮喘患者肺功能降低。
