PDF(Pubmed)
Abstract：
Poly (ADP-ribose) (PAR), a polymer of ADP-ribose, is synthesized by PAR polymerase and is crucial for the survival of cancer cells due to its vital functions in DNA repair and post-translational modifications. Beyond its supportive role, PAR also triggers cancer cell death by excessive accumulation of PAR leading to an energy crisis and parthanatos. This phenomenon underscores the potential of targeting PAR regulation as a novel anticancer strategy, and the rationale would present an engaging topic in the field of anticancer research. Therefore, this editorial provides an overview of the mechanisms determining cancer cell fate, emphasizing the central role of PAR. It further introduces promising methods for modulating PAR concentrations that may pave the way for innovative anticancer therapies.
摘要：
聚(ADP-核糖)(PAR),一种ADP-核糖的聚合物,由PAR聚合酶合成，由于其在DNA修复和翻译后修饰中的重要功能，对癌细胞的存活至关重要。除了它的支持作用，PAR还通过PAR的过度积累引发癌细胞死亡，导致能源危机和parthanatos。这种现象强调了靶向PAR调节作为一种新型抗癌策略的潜力。其基本原理将在抗癌研究领域提出一个引人入胜的话题。因此,这篇社论概述了决定癌细胞命运的机制，强调PAR的核心作用。它进一步介绍了用于调节PAR浓度的有前途的方法，这可能为创新的抗癌疗法铺平道路。
