PDF(Pubmed)
Abstract：
UNASSIGNED: Evidence from animal and human studies suggests glutamatergic dysfunction in posttraumatic stress disorder (PTSD). The purpose of this study was to investigate glutamate abnormalities in the dorsolateral prefrontal cortex (DLFPC) of individuals with PTSD using 7T MRS, which has better spectral resolution and signal-to-noise ratio than lower field strengths, thus allowing for better spectral quality and higher sensitivity. We hypothesized that individuals with PTSD would have lower glutamate levels compared to trauma-exposed individuals without PTSD and individuals without trauma exposure. Additionally, we explored potential alterations in other neurometabolites and the relationship between glutamate and psychiatric symptoms.
UNASSIGNED: Individuals with PTSD (n=27), trauma-exposed individuals without PTSD (n=27), and individuals without trauma exposure (n=26) underwent 7T MRS to measure glutamate and other neurometabolites in the left DLPFC. The severities of PTSD, depression, anxiety, and dissociation symptoms were assessed.
UNASSIGNED: We found that glutamate was lower in the PTSD and trauma-exposed groups compared to the group without trauma exposure. Furthermore, N-acetylaspartate (NAA) was lower and lactate was higher in the PTSD group compared to the group without trauma exposure. Glutamate was negatively correlated with depression symptom severity in the PTSD group. Glutamate was not correlated with PTSD symptom severity.
UNASSIGNED: In this first 7T MRS study of PTSD, we observed altered concentrations of glutamate, NAA, and lactate. Our findings provide evidence for multiple possible pathological processes in individuals with PTSD. High-field MRS offers insight into the neurometabolic alterations associated with PTSD and is a powerful tool to probe trauma- and stress-related neurotransmission and metabolism in vivo.
UNASSIGNED: Individuals with PTSD (n=27), trauma-exposed individuals without PTSD (n=27), and individuals without trauma exposure (n=26) underwent 7T MRS to measure glutamate and other neurometabolites in the left DLPFC. The severities of PTSD, depression, anxiety, and dissociation symptoms were assessed.
UNASSIGNED: We found that glutamate was lower in the PTSD and trauma-exposed groups compared to the group without trauma exposure. Furthermore, N-acetylaspartate (NAA) was lower and lactate was higher in the PTSD group compared to the group without trauma exposure. Glutamate was negatively correlated with depression symptom severity in the PTSD group. Glutamate was not correlated with PTSD symptom severity.
UNASSIGNED: In this first 7T MRS study of PTSD, we observed altered concentrations of glutamate, NAA, and lactate. Our findings provide evidence for multiple possible pathological processes in individuals with PTSD. High-field MRS offers insight into the neurometabolic alterations associated with PTSD and is a powerful tool to probe trauma- and stress-related neurotransmission and metabolism in vivo.
摘要：
■来自动物和人类研究的证据表明，创伤后应激障碍（PTSD）的谷氨酸能功能障碍。本研究的目的是使用7TMRS研究PTSD患者的背外侧前额叶皮质（DLFPC）的谷氨酸异常，与较低的场强相比，具有更好的光谱分辨率和信噪比，从而允许更好的光谱质量和更高的灵敏度。我们假设，与没有创伤后应激障碍的创伤暴露者和没有创伤暴露者相比，患有创伤后应激障碍的个体的谷氨酸水平较低。此外,我们探讨了其他神经代谢产物的潜在改变以及谷氨酸与精神症状之间的关系.
■患有PTSD的个人（n=27），没有创伤后应激障碍的创伤暴露者(n=27)，无创伤暴露的个体(n=26)接受7TMRS测量左侧DLPFC中的谷氨酸和其他神经代谢产物。创伤后应激障碍的严重性，抑郁症,焦虑,和解离症状进行了评估。
■我们发现，与没有创伤暴露的组相比，PTSD和创伤暴露组的谷氨酸较低。此外，与无创伤暴露组相比，PTSD组的N-乙酰天冬氨酸（NAA）较低，乳酸较高。PTSD组谷氨酸与抑郁症状严重程度呈负相关。谷氨酸与PTSD症状严重程度无关。
■在这项关于创伤后应激障碍的7TMRS研究中，我们观察到谷氨酸浓度的改变，NAA,和乳酸。我们的发现为PTSD患者的多种可能的病理过程提供了证据。高场MRS提供了与PTSD相关的神经代谢改变的洞察力，并且是在体内探测与创伤和压力相关的神经传递和代谢的强大工具。
■患有PTSD的个人（n=27），没有创伤后应激障碍的创伤暴露者(n=27)，无创伤暴露的个体(n=26)接受7TMRS测量左侧DLPFC中的谷氨酸和其他神经代谢产物。创伤后应激障碍的严重性，抑郁症,焦虑,和解离症状进行了评估。
■我们发现，与没有创伤暴露的组相比，PTSD和创伤暴露组的谷氨酸较低。此外，与无创伤暴露组相比，PTSD组的N-乙酰天冬氨酸（NAA）较低，乳酸较高。PTSD组谷氨酸与抑郁症状严重程度呈负相关。谷氨酸与PTSD症状严重程度无关。
■在这项关于创伤后应激障碍的7TMRS研究中，我们观察到谷氨酸浓度的改变，NAA,和乳酸。我们的发现为PTSD患者的多种可能的病理过程提供了证据。高场MRS提供了与PTSD相关的神经代谢改变的洞察力，并且是在体内探测与创伤和压力相关的神经传递和代谢的强大工具。
