PDF(Pubmed)
Abstract：
UNASSIGNED: This study evaluated the gingival crevicular fluid (GCF) and Peri- implant crevicular fluid (PICF) concentrations of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and active metalloproteinase-8 (a-MMP-8) in sites with healthy conditions vs. sites affected by periodontitis (PER) and peri-implantitis (PIM).
UNASSIGNED: Periodontally healthy (PH) sites with PER, sites with peri-implant health (PIH), and sites with PIM were investigated intra-individually, according to the inclusion criteria of each group. Probing pocket depth (PPD), plaque index, gingival index, and the presence or absence of bleeding on probing (BoP) were evaluated. In GCF and PICF samples, IL-1β, IL-6, and TNF-α were quantified by ELISA Duoset® kit in combination with Ultramark® micro-ELISA digital reader; a-MMP8 concentration was analyzed by a chairside test (Perio/ImplantSafe®) in combination with a digital reader (ORALyzer®).
UNASSIGNED: The concentrations of IL-6 and IL-1β, TNF-α, and a-MMP-8 were significantly higher in the PIM and PER sites compared to healthy sites (P<0.05). Significantly higher concentrations of IL-1β and a-MMP-8 were found in PIM vs. PER sites (P<0.05), while the concentrations of IL-6 and TNF-α did not differ between the PIM and PER groups (P>0.05).
UNASSIGNED: aMMP-8, IL-6, IL-1β, and TNF-α presented higher GCF/PICF concentrations in diseased periodontal and peri-implant sites. However, only the concentrations of IL-1β and a-MMP-8 were significantly higher in PIM than in PER sites.
UNASSIGNED: Periodontally healthy (PH) sites with PER, sites with peri-implant health (PIH), and sites with PIM were investigated intra-individually, according to the inclusion criteria of each group. Probing pocket depth (PPD), plaque index, gingival index, and the presence or absence of bleeding on probing (BoP) were evaluated. In GCF and PICF samples, IL-1β, IL-6, and TNF-α were quantified by ELISA Duoset® kit in combination with Ultramark® micro-ELISA digital reader; a-MMP8 concentration was analyzed by a chairside test (Perio/ImplantSafe®) in combination with a digital reader (ORALyzer®).
UNASSIGNED: The concentrations of IL-6 and IL-1β, TNF-α, and a-MMP-8 were significantly higher in the PIM and PER sites compared to healthy sites (P<0.05). Significantly higher concentrations of IL-1β and a-MMP-8 were found in PIM vs. PER sites (P<0.05), while the concentrations of IL-6 and TNF-α did not differ between the PIM and PER groups (P>0.05).
UNASSIGNED: aMMP-8, IL-6, IL-1β, and TNF-α presented higher GCF/PICF concentrations in diseased periodontal and peri-implant sites. However, only the concentrations of IL-1β and a-MMP-8 were significantly higher in PIM than in PER sites.
摘要：
■本研究评估了牙龈沟液（GCF）和种植体周围沟液（PICF）的白细胞介素-1β（IL-1β）浓度，白细胞介素-6（IL-6），肿瘤坏死因子-α（TNF-α）和活性金属蛋白酶-8（a-MMP-8）在健康疾病部位与受牙周炎（PER）和种植体周围炎（PIM）影响的部位。
■具有PER的牙周健康（PH）部位，种植体周围健康(PIH)的部位，与PIM的网站进行了单独调查，根据各组的纳入标准。探测袋深度(PPD),菌斑指数,牙龈指数,并评估探查时是否存在出血（BoP）。在GCF和PICF样品中，IL-1β,IL-6和TNF-α通过ELISADuoset®试剂盒与Ultramark®微ELISA数字阅读器组合进行定量;a-MMP8浓度通过椅子测试(Perio/ImplantSafe®)与数字阅读器(ORALyzer®)组合进行分析。
■IL-6和IL-1β的浓度，TNF-α,与健康部位相比，PIM和PER部位的a-MMP-8明显更高（P<0.05）。在PIM中发现显著更高浓度的IL-1β和a-MMP-8。每个部位（P<0.05），而IL-6和TNF-α的浓度在PIM组和PER组之间没有差异(P>0.05)。
■aMMP-8，IL-6，IL-1β，和TNF-α在患病的牙周和种植体周围部位呈现较高的GCF/PICF浓度。然而,PIM中只有IL-1β和a-MMP-8的浓度显着高于PER位点。
■具有PER的牙周健康（PH）部位，种植体周围健康(PIH)的部位，与PIM的网站进行了单独调查，根据各组的纳入标准。探测袋深度(PPD),菌斑指数,牙龈指数,并评估探查时是否存在出血（BoP）。在GCF和PICF样品中，IL-1β,IL-6和TNF-α通过ELISADuoset®试剂盒与Ultramark®微ELISA数字阅读器组合进行定量;a-MMP8浓度通过椅子测试(Perio/ImplantSafe®)与数字阅读器(ORALyzer®)组合进行分析。
■IL-6和IL-1β的浓度，TNF-α,与健康部位相比，PIM和PER部位的a-MMP-8明显更高（P<0.05）。在PIM中发现显著更高浓度的IL-1β和a-MMP-8。每个部位（P<0.05），而IL-6和TNF-α的浓度在PIM组和PER组之间没有差异(P>0.05)。
■aMMP-8，IL-6，IL-1β，和TNF-α在患病的牙周和种植体周围部位呈现较高的GCF/PICF浓度。然而,PIM中只有IL-1β和a-MMP-8的浓度显着高于PER位点。
